{"doi":"10.1016/j.devcel.2008.11.006","title":"RETRACTED: Dystroglycan and Perlecan Provide a Basal Cue Required for Epithelial Polarity during Energetic Stress","abstract":null,"journal":"Developmental Cell","year":2009,"id":622457,"datarank":0.6064576901751826,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":0.0,"self_endowment_contribution":0.6064576901751826,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1608330,"name":"Christina P. Christoforou","orcid":null,"position":1,"is_corresponding":false},{"id":459119,"name":"Cornelia Fritsch","orcid":"0000-0002-2964-573X","position":2,"is_corresponding":false},{"id":1608333,"name":"Daniel St. Johnston","orcid":null,"position":3,"is_corresponding":false},{"id":1608334,"name":"Robert P. Ray","orcid":null,"position":4,"is_corresponding":false},{"id":459124,"name":"Vincent Mirouse","orcid":"0000-0001-5823-342X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"RETRACTED: Dystroglycan and Perlecan Provide a Basal Cue Required for Epithelial Polarity during Energetic Stress","abstract":"Dystroglycan localizes to the basal domain of epithelial cells and has been reported to play a role in apical-basal polarity. Here, we show that Dystroglycan null mutant follicle cells have normal apical-basal polarity, but lose the planar polarity of their basal actin stress fibers, a phenotype it shares with Dystrophin mutants. However, unlike Dystrophin mutants, mutants in Dystroglycan or in its extracellular matrix ligand Perlecan lose polarity under energetic stress. The maintenance of epithelial polarity under energetic stress requires the activation of Myosin II by the cellular energy sensor AMPK. Starved Dystroglycan or Perlecan null cells activate AMPK normally, but do not activate Myosin II. Thus, Perlecan signaling through Dystroglycan may determine where Myosin II can be activated by AMPK, thereby providing the basal polarity cue for the low-energy epithelial polarity pathway. Since Dystroglycan is often downregulated in tumors, loss of this pathway may play a role in cancer progression.","is_dataset_classified":null,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19154720","pmcid":"PMC2789236","openalex_id":"https://openalex.org/W2159952016","authors":[],"funders":[{"funder_name":"Cancer Research UK","grant_id":"A14492","title":null},{"funder_name":"Wellcome Trust","grant_id":"080007","title":null},{"funder_name":"Medical Research Council","grant_id":"G0500916","title":null},{"funder_name":"Wellcome Trust","grant_id":"092096","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"","title":null}],"total_grants":6,"fwci":5.1619,"citation_percentile":0.96483069,"influential_citations":0,"citation_trend":[{"year":2012,"count":11},{"year":2013,"count":3},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2020,"count":1},{"year":2022,"count":1},{"year":2023,"count":2}],"oa_status":"closed","license":"http://creativecommons.org/licenses/by-nc-nd/3.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1534580708004802?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580708004802?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.devcel.2008.11.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19154720","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28898630","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2789236","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5638935","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2789236","host_type":"Europe_PMC"}],"fields_of_study":["Muscle Physiology and Disorders","Cellular Mechanics and Interactions","Hippo pathway signaling and YAP/TAZ","AMP-Activated Protein Kinases","Animals","Cell Polarity","Drosophila Proteins","Drosophila melanogaster","Dystroglycans","Epithelial Cells","Female","Heparan Sulfate Proteoglycans","Humans","Male","Myosin Type II","Oocytes","Ovarian Follicle","Phenotype","Signal Transduction","Stress Fibers","Stress, Physiological"],"mesh_terms":["Animals","Drosophila melanogaster","Epithelial Cells","Female","Ovarian Follicle","Humans","Male","Oocytes","Phenotype","Stress, Physiological","Signal Transduction","Cell Polarity","Heparan Sulfate Proteoglycans","Stress Fibers","Myosin Type II","Drosophila Proteins","Dystroglycans","AMP-Activated Protein Kinases"],"keywords":["Perlecan","Dystroglycan","Cell biology","Biology","Polarity (international relations)","Laminin","Cell polarity","Epithelial polarity","Dystrophin","Extracellular matrix","Muscular dystrophy","Proteoglycan","Biochemistry","Genetics","Epithelium"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T19:42:32.420054Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}