{"doi":"10.1016/j.devcel.2006.11.003","title":"Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation","abstract":null,"journal":"Developmental Cell","year":2007,"id":670243,"datarank":0.8614504781714225,"base_score":5.7430031878094825,"endowment":5.7430031878094825,"self_citation_contribution":0.8614504781714225,"citation_network_contribution":0.0,"self_endowment_contribution":0.8614504781714225,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":311,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576047,"name":"Kyu Sang Joeng","orcid":"0000-0002-1978-0575","position":1,"is_corresponding":false},{"id":112032,"name":"Keiichi I. Nakayama","orcid":"0000-0002-7185-1529","position":2,"is_corresponding":false},{"id":1750653,"name":"Keiko Nakayama","orcid":null,"position":3,"is_corresponding":false},{"id":547129,"name":"Jayaraj Rajagopal","orcid":"0000-0003-3190-8647","position":4,"is_corresponding":false},{"id":1750655,"name":"Thomas J. Carroll","orcid":null,"position":5,"is_corresponding":false},{"id":215134,"name":"Andrew P. McMahon","orcid":null,"position":6,"is_corresponding":false},{"id":232256,"name":"Fanxin Long","orcid":"0000-0001-9785-5379","position":7,"is_corresponding":false},{"id":919275,"name":"Xiaolin Tu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation","abstract":"Wnt signaling regulates a variety of developmental processes in animals. Although the beta-catenin-dependent (canonical) pathway is known to control cell fate, a similar role for noncanonical Wnt signaling has not been established in mammals. Moreover, the intracellular cascades for noncanonical Wnt signaling remain to be elucidated. Here, we delineate a pathway in which Wnt3a signals through the Galpha(q/11) subunits of G proteins to activate phosphatidylinositol signaling and PKCdelta in the murine ST2 cells. Galpha(q/11)-PKCdelta signaling is required for Wnt3a-induced osteoblastogenesis in these cells, and PKCdelta homozygous mutant mice exhibit a deficit in embryonic bone formation. Furthermore, Wnt7b, expressed by osteogenic cells in vivo, induces osteoblast differentiation in vitro via the PKCdelta-mediated pathway; ablation of Wnt7b in skeletal progenitors results in less bone in the mouse embryo. Together, these results reveal a Wnt-dependent osteogenic mechanism, and they provide a potential target pathway for designing therapeutics to promote bone formation.","is_dataset_classified":null,"base_score":5.7430031878094825,"endowment":5.7430031878094825,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17199045","pmcid":"PMC1861818","openalex_id":"https://openalex.org/W2118807251","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"P01 DK056246","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK065789","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"P01 HD070394","title":null}],"total_grants":3,"fwci":10.1921,"citation_percentile":0.99008711,"influential_citations":0,"citation_trend":[{"year":2012,"count":18},{"year":2013,"count":24},{"year":2014,"count":24},{"year":2015,"count":13},{"year":2016,"count":13},{"year":2017,"count":10},{"year":2018,"count":14},{"year":2019,"count":10},{"year":2020,"count":11},{"year":2021,"count":10},{"year":2022,"count":19},{"year":2023,"count":8},{"year":2024,"count":14},{"year":2025,"count":12},{"year":2026,"count":7}],"oa_status":"bronze","license":"https://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"http://www.cell.com/article/S1534580706005089/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1534580706005089/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580706005089?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1534580706005089?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.devcel.2006.11.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17199045","host_type":"repository"}],"fields_of_study":["Wnt/β-catenin signaling in development and cancer","Cancer-related gene regulation","Connective tissue disorders research","Adaptor Proteins, Signal Transducing","Animals","Bone and Bones","Cell Differentiation","Culture Media, Conditioned","Dishevelled Proteins","Embryo, Mammalian","Enzyme Activation","GTP-Binding Protein alpha Subunits, Gq-G11","Gene Deletion","Gene Expression Regulation, Developmental","Glycoproteins","Intercellular Signaling Peptides and Proteins","Intracellular Signaling Peptides and Proteins","Membrane Proteins","Mice","Myristoylated Alanine-Rich C Kinase Substrate","Osteoblasts","Osteogenesis","Phosphatidylinositols","Phosphoproteins","Phosphorylation","Protein Kinase C-delta","Proto-Oncogene Proteins","RNA, Messenger","Signal Transduction","Wnt Proteins","Wnt3 Protein","Wnt3A Protein","beta Catenin"],"mesh_terms":["Dishevelled Proteins","Myristoylated Alanine-Rich C Kinase Substrate","Animals","Bone and Bones","Cell Differentiation","Embryo, Mammalian","Enzyme Activation","Glycoproteins","Membrane Proteins","Osteoblasts","Osteogenesis","Phosphatidylinositols","Phosphoproteins","Phosphorylation","Proto-Oncogene Proteins","RNA, Messenger","Signal Transduction","Culture Media, Conditioned","Gene Deletion","Gene Expression Regulation, Developmental","Intercellular Signaling Peptides and Proteins","GTP-Binding Protein alpha Subunits, Gq-G11","Intracellular Signaling Peptides and Proteins","Adaptor Proteins, Signal Transducing","Wnt Proteins","beta Catenin","Mice","Protein Kinase C-delta","Wnt3 Protein","Wnt3A Protein"],"keywords":["Biology","Wnt signaling pathway","Protein kinase C","Cell biology","Signal transduction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T21:03:57.727110Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}