{"doi":"10.1016/j.dcn.2020.100788","title":"Leveraging multi-shell diffusion for studies of brain development in youth and young adulthood","abstract":"Diffusion weighted imaging (DWI) has advanced our understanding of brain microstructure evolution over development. Recently, the use of multi-shell diffusion imaging sequences has coincided with advances in modeling the diffusion signal, such as Neurite Orientation Dispersion and Density Imaging (NODDI) and Laplacian-regularized Mean Apparent Propagator MRI (MAPL). However, the relative utility of recently-developed diffusion models for understanding brain maturation remains sparsely investigated. Additionally, despite evidence that motion artifact is a major confound for studies of development, the vulnerability of metrics derived from contemporary models to in-scanner motion has not been described. Accordingly, in a sample of 120 youth and young adults (ages 12-30) we evaluated metrics derived from diffusion tensor imaging (DTI), NODDI, and MAPL for associations with age and in-scanner head motion at multiple scales. Specifically, we examined mean white matter values, white matter tracts, white matter voxels, and connections in structural brain networks. Our results revealed that multi-shell diffusion imaging data can be leveraged to robustly characterize neurodevelopment, and demonstrate stronger age effects than equivalent single-shell data. Additionally, MAPL-derived metrics were less sensitive to the confounding effects of head motion. Our findings suggest that multi-shell imaging data and contemporary modeling techniques confer important advantages for studies of neurodevelopment.","journal":"Developmental Cognitive Neuroscience","year":2020,"id":55314,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":94,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":285909,"name":"Matthew Cieslak","orcid":"0000-0002-1931-4734","position":1,"is_corresponding":false},{"id":274058,"name":"Bart Larsen","orcid":"0000-0001-7896-4342","position":2,"is_corresponding":false},{"id":235288,"name":"Graham L. Baum","orcid":"0009-0008-5123-5535","position":3,"is_corresponding":false},{"id":233666,"name":"Philip A. Cook","orcid":"0000-0002-1985-8475","position":4,"is_corresponding":false},{"id":235287,"name":"Azeez Adebimpe","orcid":"0000-0001-9049-0135","position":5,"is_corresponding":false},{"id":287281,"name":"Diego Davila","orcid":null,"position":6,"is_corresponding":false},{"id":275710,"name":"Mark A. Elliott","orcid":"0000-0003-4191-5509","position":7,"is_corresponding":false},{"id":285910,"name":"Robert J. Jirsaraie","orcid":"0000-0002-8372-7816","position":8,"is_corresponding":false},{"id":285911,"name":"Kristin Murtha","orcid":"0009-0006-5820-6740","position":9,"is_corresponding":false},{"id":235290,"name":"Desmond J. Oathes","orcid":"0000-0001-7346-2669","position":10,"is_corresponding":false},{"id":287282,"name":"Kayla Piiwaa","orcid":null,"position":11,"is_corresponding":false},{"id":285912,"name":"Adon F.G. Rosen","orcid":"0000-0002-8506-5561","position":12,"is_corresponding":false},{"id":287283,"name":"Sage Rush","orcid":null,"position":13,"is_corresponding":false},{"id":52271,"name":"Russell T. Shinohara","orcid":"0000-0001-8627-8203","position":14,"is_corresponding":false},{"id":103395,"name":"Danielle S. Bassett","orcid":"0000-0002-6183-4493","position":15,"is_corresponding":false},{"id":235291,"name":"David R. Roalf","orcid":"0000-0002-1728-9782","position":16,"is_corresponding":false},{"id":230040,"name":"Theodore D. Satterthwaite","orcid":"0000-0001-7072-9399","position":17,"is_corresponding":false},{"id":285908,"name":"Adam Pines","orcid":"0000-0001-9740-3196","position":0,"is_corresponding":true}],"reference_count":108,"raw_metadata":null,"created_at":"2026-07-18T21:04:59.506324Z","pmid":"32510347","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}