{"doi":"10.1016/j.dci.2021.104078","title":"Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation","abstract":null,"journal":"Developmental &amp; Comparative Immunology","year":2021,"id":637543,"datarank":0.5495342469194471,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.0,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":379174,"name":"Peng Jin","orcid":"0000-0003-4363-9894","position":1,"is_corresponding":false},{"id":242218,"name":"Hao Chen","orcid":"0000-0002-8874-0673","position":2,"is_corresponding":false},{"id":495234,"name":"Di Wu","orcid":"0000-0002-3238-6388","position":3,"is_corresponding":false},{"id":125783,"name":"Shuxin Li","orcid":"0009-0003-0468-2029","position":4,"is_corresponding":false},{"id":1579549,"name":"Yuanxing Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":748163,"name":"Qin Liu","orcid":"0000-0002-9352-1694","position":6,"is_corresponding":false},{"id":1655487,"name":"Dahai Yang","orcid":"0000-0001-6602-8653","position":7,"is_corresponding":false},{"id":1655484,"name":"Shouwen Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation","abstract":"Host protective inflammatory caspase activity must be tightly regulated to prevent pathogens infection, however, the inflammatory caspase-engaged inflammasome activation in teleost fish remains largely unknown. In this study, we reveal a bifurcated evolutionary role of the inflammatory caspase in mediating both non-canonical and canonical inflammasome pathways in teleost fish. Through characterization of a unique inflammatory SmCaspase from the teleost Scophthalmus maximus (turbot), we found it can directly recognize cytosolic lipopolysaccharide (LPS) via its N-terminal CARD domain, resulting in caspase-5-like proteolytic enzyme activity-mediated pyroptosis in Turbot Muscle Fibroblasts. Interestingly, we also found that this inflammatory caspase can be recruited to SmNLRP3-SmASC to form the NLRP3 inflammasome complex, engaging the SmIL-1β release in Head Kidney-derived Macrophages. Consequently, the SmCaspase activation can recognize and cleave the SmGSDMEb to release its N-terminal domain, mediating both pyroptosis and bactericidal activities. Furthermore, the SmCaspase-SmGSDMEb axis-gated pyroptosis governs the bacterial clearance and epithelial desquamation in fish gill filaments in vivo. To our knowledge, this study is the first to identify an inflammatory caspase acting as a central coordinator in NLRP3 inflammasome, as well as a cytosolic LPS receptor; thus uncovering a previously unrecognized function of inflammatory caspase in turbot innate immunity.","is_dataset_classified":null,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33794278","pmcid":null,"openalex_id":"https://openalex.org/W3146986594","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"","title":null}],"total_grants":1,"fwci":2.2955,"citation_percentile":0.89438112,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":8},{"year":2023,"count":13},{"year":2024,"count":9},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0145305X21000860?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0145305X21000860?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.dci.2021.104078","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33794278","host_type":"repository"}],"fields_of_study":["Inflammasome and immune disorders","Heme Oxygenase-1 and Carbon Monoxide","Toxoplasma gondii Research Studies"],"mesh_terms":["Pyroptosis","NLR Family, Pyrin Domain-Containing 3 Protein","Caspase Activation and Recruitment Domain","Animals","Flatfishes","HeLa Cells","Humans","Immunity, Innate","Lipopolysaccharides","Macrophages","Membrane Proteins","Phylogeny","Computational Biology","Caspases","Edwardsiella","Fish Proteins","HEK293 Cells","Inflammasomes","Head Kidney","Hela Cells"],"keywords":["Pyroptosis","Inflammasome","AIM2","Caspase 1","Innate immune system","Biology","Cell biology","Pyrin domain","Turbot","Inflammation","NLRC4","Immunology","Immune system","Fish <Actinopterygii>","Antibacterial activity","Nlrp3 Inflammasome","Gsdme","Inflammatory Caspase","Cytosolic Lps Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T19:08:37.548419Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}