{"doi":"10.1016/j.dci.2015.10.020","title":"Anopheles gambiae hemocytes exhibit transient states of activation","abstract":null,"journal":"Developmental & Comparative Immunology","year":2016,"id":666571,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":568644,"name":"Kristin Michel","orcid":"0000-0001-9769-5248","position":1,"is_corresponding":false},{"id":445213,"name":"William B. Bryant","orcid":"0000-0002-3332-4330","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Anopheles gambiae hemocytes exhibit transient states of activation","abstract":"Hemocytes are crucial players of the mosquito immune system and critically affect transmission of pathogens including malaria parasites. We and others discovered previously that a blood meal is a major immune stimulus for mosquito hemocytes. To determine whether these blood meal-induced hemocyte changes in Anopheles gambiae constitute steps in cell differentiation or demonstrate transient cell activation, we analyzed the temporal pattern of these changes over the first three days post blood meal (dpbm). Flow cytometry and immunofluorescence analyses revealed a global shift of the entire hemocyte population, peaking at 1 dpbm. All hemocyte activation markers returned to pre-blood meal baseline levels within the following 24-48 h. Our observations are consistant with An. gambiae hemocytes undergoing transient activation rather than terminal differentiation upon blood feeding. Interestingly, the temporal pattern followed the gonotrophic cycle of the mosquito, strongly suggesting hormonal control of mosquito hemocyte activation and deactivation.","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26515540","pmcid":"PMC4685016","openalex_id":"https://openalex.org/W2200794118","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01-AI095842","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"F32 AI104154","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"F32-AI104154","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI095842","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases","grant_id":"","title":null}],"total_grants":5,"fwci":1.8951,"citation_percentile":0.8586145,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":3},{"year":2017,"count":7},{"year":2018,"count":4},{"year":2019,"count":6},{"year":2020,"count":5},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":4},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0145305X15300641?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0145305X15300641?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.dci.2015.10.020","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26515540","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4685016","host_type":"repository"}],"fields_of_study":["Invertebrate Immune Response Mechanisms","Mosquito-borne diseases and control","Aquaculture disease management and microbiota"],"mesh_terms":["Animals","Anopheles","Blood","Cell Differentiation","Cells, Cultured","Eating","Hemocytes","Hormones","Immunization","Life Cycle Stages"],"keywords":["Anopheles gambiae","Transient (computer programming)","Cell biology","Biology","Biophysics","Materials science","Biological system","Computer science","Immunology","Malaria","Cellular immunity","Mosquito","innate immunity","Host–pathogen Interactions"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T14:52:35.741630Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}