{"doi":"10.1016/j.dci.2009.02.001","title":"Transferrin and ferritin response to bacterial infection: The role of the liver and brain in fish","abstract":null,"journal":"Developmental & Comparative Immunology","year":2009,"id":605758,"datarank":0.7747178960885273,"base_score":5.1647859739235145,"endowment":5.1647859739235145,"self_citation_contribution":0.7747178960885273,"citation_network_contribution":0.0,"self_endowment_contribution":0.7747178960885273,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":174,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":456875,"name":"Jonathan M. Wilson","orcid":"0000-0002-8648-600X","position":1,"is_corresponding":false},{"id":1554771,"name":"Pedro N.S. Rodrigues","orcid":null,"position":2,"is_corresponding":false},{"id":1554769,"name":"João V. Neves","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Transferrin and ferritin response to bacterial infection: The role of the liver and brain in fish","abstract":"Iron is essential for growth and survival, but it is also toxic when in excess. Thus, there is a tight regulation of iron that is accomplished by the interaction of several genes including the iron transporter transferrin and iron storage protein ferritin. These genes are also known to be involved in response to infection. The aim of this study was to understand the role of transferrin and ferritin in infection and iron metabolism in fish. Thus, sea bass transferrin and ferritin H cDNAs were isolated from liver, cloned and characterized. Transferrin constitutive expression was found to be highest in the liver, but also with significant expression in the brain, particularly in the highly vascularized region connecting the inferior lobe of the hypothalamus and the saccus vasculosus. Ferritin, on the other hand, was expressed in all tested organs, but also significantly higher in the liver. Fish were subjected to either experimental bacterial infection or iron modulation and transferrin and ferritin mRNA expression levels were analyzed, along with several iron regulatory parameters. Transferrin expression was found to decrease in the liver and increase in the brain in response to infection and to increase in the liver in iron deficiency. Ferritin expression was found to inversely reflect transferrin in the liver, increasing in infection and iron overload and decreasing in iron deficiency, whereas in the brain, ferritin expression was also increased in infection. These findings demonstrate the evolutionary conservation of transferrin and ferritin dual functions in vertebrates, being involved in both the immune response and iron metabolism.","is_dataset_classified":null,"base_score":5.1647859739235145,"endowment":5.1647859739235145,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19428486","pmcid":null,"openalex_id":"https://openalex.org/W2003090763","authors":[],"funders":[{"funder_name":"Fundação para a Ciência e a Tecnologia","grant_id":"","title":null},{"funder_name":"Ministério da Educação e Ciência","grant_id":"","title":null}],"total_grants":2,"fwci":6.3284,"citation_percentile":0.97044677,"influential_citations":4,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":7},{"year":2014,"count":10},{"year":2015,"count":11},{"year":2016,"count":13},{"year":2017,"count":14},{"year":2018,"count":10},{"year":2019,"count":6},{"year":2020,"count":10},{"year":2021,"count":16},{"year":2022,"count":9},{"year":2023,"count":13},{"year":2024,"count":7},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0145305X0900041X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0145305X0900041X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.dci.2009.02.001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19428486","host_type":"repository"}],"fields_of_study":["Iron Metabolism and Disorders","Hemoglobinopathies and Related Disorders","Trace Elements in Health","Biology","Medicine","Environmental Science","Amino Acid Sequence","Animals","Base Sequence","Bass","Brain","Ferritins","Gram-Negative Bacterial Infections","Iron","Liver","Molecular Sequence Data","Photobacterium","Phylogeny","Sequence Alignment","Transferrin"],"mesh_terms":["Amino Acid Sequence","Animals","Base Sequence","Bass","Brain","Ferritins","Iron","Liver","Molecular Sequence Data","Photobacterium","Phylogeny","Transferrin","Sequence Alignment","Gram-Negative Bacterial Infections"],"keywords":["Transferrin","Ferritin","Transferrin receptor","Biology","Transporter","Transferrin saturation","Iron deficiency","Metabolism","Gene expression","Endocrinology","Internal medicine","Biochemistry","Medicine","Gene","Serum ferritin","Anemia"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.14998998.v1","title":"Additional file 1 of Deploying new generation sequencing for the study of flesh color depletion in Atlantic Salmon (Salmo salar)","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14998998","title":"Additional file 1 of Deploying new generation sequencing for the study of flesh color depletion in Atlantic Salmon (Salmo salar)","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14999001.v1","title":"Additional file 2 of Deploying new generation sequencing for the study of flesh color depletion in Atlantic Salmon (Salmo salar)","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14999001","title":"Additional file 2 of Deploying new generation sequencing for the study of flesh color depletion in Atlantic Salmon (Salmo salar)","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:11:03.022493Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}