{"doi":"10.1016/j.dadr.2025.100405","title":"Morbidity, mortality, and health outcomes following emergency department visits for fentanyl-related overdoses: A retrospective cohort study","abstract":"Background: Overdose (OD)-related mortality has been extensively studied; however, less is known about OD-related morbidity beyond neurocognitive impairments (NCI). The purpose of this study is to systematically describe morbidity, mortality, and health outcomes following a fentanyl-related OD treated in the emergency department (ED). Methods: A retrospective cohort study (n = 205) was conducted using electronic medical record (EMR) data of patients who presented to an ED for a suspected or confirmed fentanyl-related OD within a rural health system that includes 25 hospitals across 4 states. Eligible events occurred between November 1, 2021 and October 31, 2022. Results: A third (32 %) of patients were discharged the same day, 6 % were hospitalized for 10 + days, 34 % were transferred to the intensive care unit (ICU) and 8 % died during their hospitalization. Twenty-three patients had ongoing health conditions that necessitated transfer to another inpatient hospital or a skilled nursing facility. Among the 633 diagnoses recorded, the majority (64 %) were categorized as related to the OD and specifically 20 % of patients had amnesia or memory loss. Diagnoses were also categorized as mental health (17 %) and medical conditions (11 %). A third of patients were administered naloxone in the hospital and other medication administered included gastrointestinal agents, central nervous system agents and analgesics. Conclusion: Patients treated in the ED for a non-fatal OD had significant hospital service utilization and had complex morbidity suggesting the need for coordinated aftercare, as well as screening for NCI.","journal":"Drug and Alcohol Dependence Reports","year":2025,"id":537551,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6643,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1423352,"name":"Samantha Nash","orcid":"0000-0003-3772-5614","position":1,"is_corresponding":false},{"id":1423781,"name":"Baylee Farmer","orcid":null,"position":2,"is_corresponding":false},{"id":1423353,"name":"Zebulun Mallow","orcid":"0000-0002-0949-0814","position":3,"is_corresponding":false},{"id":459712,"name":"Liv E. Miller","orcid":"0000-0001-8698-5442","position":4,"is_corresponding":false},{"id":1423782,"name":"E. Ashley Six-Workman","orcid":null,"position":5,"is_corresponding":false},{"id":272450,"name":"James J. Mahoney","orcid":"0000-0003-0824-1776","position":6,"is_corresponding":false},{"id":281555,"name":"Erin L. Winstanley","orcid":"0000-0003-3571-0259","position":7,"is_corresponding":false},{"id":1423351,"name":"Lyn Yuen Choo","orcid":"0000-0001-5640-0749","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:52:12.997494Z","pmid":"41550420","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}