{"doi":"10.1016/j.dadr.2022.100100","title":"Time-lagged association between counseling and/or 12-Step attendance with subsequent opioid use in a secondary analysis from a randomized, clinical trial of medications for opioid use disorder","abstract":"Psychosocial support is recommended in conjunction with medication for opioid use disorder (MOUD), although optimal “dose,” modality, and timing of participation is not established. This study comprised a secondary analysis of counseling and 12-Step attendance and subsequent opioid use in a MOUD randomized clinical trial. Methods: The parent study randomly assigned 570 participants to receive buprenorphine-naloxone (BUP-NX, n=287) or extended-release injectable naltrexone (XR-NTX, n=283). Mixed-effects logistic regression models were fit with opioid use as the response variable, and a counseling/12-Step attendance predictor. Differences by treatment assignment were examined. Results: Any counseling or 12-Step attendance was associated with reduced odds of opioid use at the subsequent visit, whether considered individually or aggregated across type. A continuous relationship was observed for 12-Step attendance (F(1,5083)=5.01, p=.025); with each additional hour associated with 13% (95% CI: 0.83, 0.90) reduction in odds of opioid use. The strength of this association grew over time. In the BUP-NX arm, group counseling was associated with a greater reduction in odds of opioid use than for XR-NTX, (OR=0.32 (95% CI: .22, 0.48) vs. OR=0.69 (95% CI: 0.43, 1.08)). For XR-NTX, 12-Step was associated with a greater reduction in odds of opioid use (OR=0.35 (95% CI: 0.22, 0.54) vs. OR=0.65 (95% CI: 0.47, 0.89) for BUP-NX)). Conclusions: Psychosocial engagement has a proximal association with opioid use, the strength of that association may grow with dose and time. Alternatively, more motivated individuals may both attend more counseling/12-Step and have better treatment outcomes, or the relationship may be reciprocal.","journal":"Drug and Alcohol Dependence Reports","year":2022,"id":293288,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":353625,"name":"Tse‐Hwei Choo","orcid":"0000-0001-5068-9799","position":1,"is_corresponding":false},{"id":451486,"name":"Dikla Shmueli‐Blumberg","orcid":"0000-0002-0788-5767","position":2,"is_corresponding":false},{"id":366308,"name":"Martina Pavlicová","orcid":"0000-0003-4400-4102","position":3,"is_corresponding":false},{"id":978007,"name":"Jacquie King","orcid":null,"position":4,"is_corresponding":false},{"id":414546,"name":"Marc Fishman","orcid":"0000-0001-6764-6410","position":5,"is_corresponding":false},{"id":896906,"name":"Matisyahu Shulman","orcid":"0000-0002-2941-8895","position":6,"is_corresponding":false},{"id":281557,"name":"Aimee Campbell","orcid":"0000-0003-4247-9980","position":7,"is_corresponding":false},{"id":977685,"name":"Miranda Greiner","orcid":"0000-0003-3768-527X","position":8,"is_corresponding":false},{"id":388957,"name":"Jennifer Scodes","orcid":"0000-0002-5006-7436","position":9,"is_corresponding":false},{"id":941683,"name":"Sarah Meyers-Ohki","orcid":null,"position":10,"is_corresponding":false},{"id":775474,"name":"Patricia Novo","orcid":null,"position":11,"is_corresponding":false},{"id":299659,"name":"Edward V. Nunes","orcid":"0000-0002-2055-3425","position":12,"is_corresponding":false},{"id":513471,"name":"John Rotrosen","orcid":"0000-0002-0283-5576","position":13,"is_corresponding":false},{"id":896905,"name":"Kathryn Hefner","orcid":"0000-0002-5208-7860","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:50.076284Z","pmid":"36644220","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}