{"doi":"10.1016/j.cyto.2012.06.287","title":"Osteopontin regulates interleukin-17 production in hepatitis","abstract":null,"journal":"Cytokine","year":2012,"id":635678,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":907374,"name":"Xiangdong Liu","orcid":"0000-0001-5358-1492","position":1,"is_corresponding":false},{"id":1556753,"name":"Zhongwen Wu","orcid":null,"position":2,"is_corresponding":false},{"id":1174066,"name":"Lei Kang","orcid":"0000-0002-9993-6399","position":3,"is_corresponding":false},{"id":1556750,"name":"Guangying Cui","orcid":null,"position":4,"is_corresponding":false},{"id":128139,"name":"Junko Morimoto","orcid":null,"position":5,"is_corresponding":false},{"id":11157,"name":"David T. Denhardt","orcid":null,"position":6,"is_corresponding":false},{"id":1649312,"name":"Susan Rittling","orcid":null,"position":7,"is_corresponding":false},{"id":608927,"name":"Yoichiro Iwakura","orcid":"0000-0002-9934-5775","position":8,"is_corresponding":false},{"id":1649313,"name":"Toshimitsu Uede","orcid":null,"position":9,"is_corresponding":false},{"id":72026,"name":"Lanjuan Li","orcid":"0000-0001-6945-0593","position":10,"is_corresponding":false},{"id":1556755,"name":"Hongyan Diao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Osteopontin regulates interleukin-17 production in hepatitis","abstract":"The overexpression of osteopontin is associated with various inflammatory liver diseases. Interestingly, each of these diseases is also associated with IL-17 expression. Therefore, we sought to determine whether there is any mechanistic link between osteopontin and IL-17. Herein we show that IL-17 and osteopontin levels were significantly increased in patients with chronic hepatitis B. We found that IL-17 and osteopontin levels increased similarly in mice with concanavalin A-induced hepatitis. Both osteopontin- and IL-17-deficient mice were resistant to concanavalin A-induced hepatic injury. In addition, osteopontin markedly induced IL-17 expression by leukocytes (from humans and mice). This effect could be blocked by a specific antibody against osteopontin. β3 integrin (one of the osteopontin receptors) was critically involved in the induction of IL-17 production by osteopontin. Osteopontin-induced IL-17 expression was mediated through the p38, JNK, and NF-κB pathways. These findings suggest that osteopontin regulates IL-17 production during the pathogenesis of hepatitis and provide new evidence for the critical roles of osteopontin and IL-17 in hepatitis.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22818182","pmcid":null,"openalex_id":"https://openalex.org/W2060996895","authors":[],"funders":[{"funder_name":"New Century Excellent Talents","grant_id":"NCET-09-0686","title":null},{"funder_name":"Science and Technology Department Foundation of Zhejiang Province","grant_id":"2010R10061","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"2009QNA7033","title":null}],"total_grants":3,"fwci":0.828,"citation_percentile":0.73311013,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":5},{"year":2018,"count":4},{"year":2019,"count":2},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1043466612005327?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1043466612005327?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cyto.2012.06.287","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22818182","host_type":"repository"}],"fields_of_study":["Bone and Dental Protein Studies","Vitamin D Research Studies","Bone Metabolism and Diseases"],"mesh_terms":["Adult","Animals","Cells, Cultured","Concanavalin A","Drug Resistance","Enzyme Inhibitors","Enzyme-Linked Immunosorbent Assay","Female","Humans","Leukocytes, Mononuclear","Male","Mice, Inbred C57BL","Peptides","Signal Transduction","NF-kappa B","Mice, Knockout","Hepatitis B, Chronic","Interleukin-17","JNK Mitogen-Activated Protein Kinases","p38 Mitogen-Activated Protein Kinases","Mice","Osteopontin","Young Adult","Chemical and Drug Induced Liver Injury"],"keywords":["Osteopontin","Concanavalin A","Pathogenesis","Immunology","Medicine","Biology","Biochemistry","In vitro"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:26:42.247434Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}