{"doi":"10.1016/j.cub.2024.10.048","title":"Higher-order cortical and thalamic pathways shape visual processing streams in the mouse cortex","abstract":null,"journal":"Current Biology","year":2024,"id":632376,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1639166,"name":"Vincent Bonin","orcid":"0000-0002-9437-8092","position":1,"is_corresponding":false},{"id":994940,"name":"Xu Han","orcid":"0000-0003-0379-9447","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Higher-order cortical and thalamic pathways shape visual processing streams in the mouse cortex","abstract":"Mammalian visual functions rely on distributed processing across interconnected cortical and subcortical regions. In higher-order visual areas (HVAs), visual features are processed in specialized streams that integrate feedforward and higher-order inputs from intracortical and thalamocortical pathways. However, the precise circuit organization responsible for HVA specialization remains unclear. We investigated the cellular architecture of primary visual cortex (V1) and higher-order visual pathways in the mouse, focusing on their roles in shaping visual representations. Using in vivo functional imaging and neural circuit tracing, we found that HVAs preferentially receive inputs from both V1 and higher-order pathways tuned to similar spatiotemporal properties, with the strongest selectivity seen in layer 2/3 neurons. These neurons exhibit target-specific tuning and sublaminar specificity in their projections, reflecting cell-type-specific visual information flow. In contrast, HVA layer 5 pathways nonspecifically broadcast visual signals across cortical areas, suggesting a role in distributing HVA outputs. Additionally, thalamocortical pathways from the lateral posterior thalamic nucleus (LP) provide highly specific, nearly non-overlapping visual inputs to HVAs, complementing intracortical inputs and contributing to input functional diversity. Our findings suggest that the convergence of laminar and cell-type-specific pathways V1 and higher-order intracortical and thalamocortical pathways plays a key role in shaping the functional specialization and diversity of HVAs.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39566501","pmcid":null,"openalex_id":"https://openalex.org/W4404526164","authors":[],"funders":[],"total_grants":0,"fwci":2.1571,"citation_percentile":0.8771622,"influential_citations":0,"citation_trend":[{"year":2025,"count":7},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.cub.2024.10.048","host_type":"journal"},{"url":"https://doi.org/10.1016/j.cub.2024.10.048","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S096098222401443X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S096098222401443X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39566501","host_type":"repository"},{"url":"https://lirias.kuleuven.be/handle/20.500.12942/765475","host_type":"repository"},{"url":"https://lirias.kuleuven.be/retrieve/d99c63c5-c1c3-4c19-b2b2-3f3209baaecb","host_type":"repository"}],"fields_of_study":["Neural dynamics and brain function","Visual perception and processing mechanisms","Neuroscience and Neuropharmacology Research"],"mesh_terms":["Primary Visual Cortex","Animals","Female","Male","Mice, Inbred C57BL","Neurons","Thalamus","Visual Cortex","Visual Pathways","Visual Perception","Mice"],"keywords":["Biology","Visual cortex","Cortex (anatomy)","Neuroscience","STREAMS","Visual system","Thalamus","Computer science","Thalamocortical Pathway","Target Specificity","Intracortical Connectivity","Visual Streams","Broadcast Mode","Higher-order Visual Pathway","Sublaminar Specificity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:38:03.830398Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}