{"doi":"10.1016/j.cub.2020.03.056","title":"The Impact of Neutral Mutations on Genome Evolvability","abstract":null,"journal":"Current Biology","year":2020,"id":90935,"datarank":0.9548924191033108,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.47206104537308063,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.47206104537308063,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":22,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":456052,"name":"Ivan Matic","orcid":null,"position":1,"is_corresponding":false},{"id":127145,"name":"Olivier Tenaillon","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Impact of Neutral Mutations on Genome Evolvability","abstract":"Beneficial mutations are rare and deleterious mutations are purged by natural selection. As a result, the vast majority of mutations that accumulate in genomes belong to the class of neutral mutations. Over the last two decades, neutral mutations, despite their null effect on fitness, have been shown to affect evolvability by providing access to new phenotypes through subsequent mutations that would not have been available otherwise. Here we propose that in addition, many mutations - independent of their selective effects - can affect the mutability of neighboring DNA sequences and modulate the efficacy of homologous recombination. Such mutations do not change the spectrum of accessible phenotypes, but rather the rate at which new phenotypes will be produced. Therefore, neutral mutations that accumulate in genomes have an important long-term impact on the evolutionary fate of genomes.","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32428494","pmcid":null,"openalex_id":"https://openalex.org/W3024359069","authors":[],"funders":[{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-18-CE35-0005","title":"Bacterial genome wide epistasis: extant, emergence and molecular bases."},{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-11-LABX-0071","title":null},{"funder_name":"Agence Nationale de la Recherche","grant_id":"","title":null},{"funder_name":"Fondation pour la Recherche Médicale","grant_id":"","title":null}],"total_grants":4,"fwci":1.2813,"citation_percentile":0.80317887,"influential_citations":0,"citation_trend":[{"year":2022,"count":5},{"year":2023,"count":3},{"year":2024,"count":8},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S0960982220304267/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0960982220304267/pdf","host_type":"BRONZE"},{"url":"http://www.cell.com/article/S0960982220304267/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960982220304267?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960982220304267?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cub.2020.03.056","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32428494","host_type":"repository"},{"url":"https://hal.science/hal-03052120","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36219077","host_type":""},{"url":"https://dx.doi.org/10.1016/j.cub.2020.03.056","host_type":""},{"url":"https://hal.science/hal-03052120v1/document","host_type":""},{"url":"https://hal.science/hal-03052120v1","host_type":""}],"fields_of_study":["Evolution and Genetic Dynamics","CRISPR and Genetic Engineering","Genomics and Phylogenetic Studies","Biology","Medicine","0301 basic medicine","03 medical and health sciences","Animals","Biological Evolution","Genome","Models, Genetic","Mutation","Recombination, Genetic"],"mesh_terms":["Animals","Biological Evolution","Models, Genetic","Mutation","Recombination, Genetic","Genome"],"keywords":["Evolvability","Biology","Genetics","Genome","Neutral mutation","Phenotype","Mutation","Gene","Mutation rate","Neutral theory of molecular evolution","Homologous recombination","Evolutionary biology","[SDV] Life Sciences [q-bio]","Recombination, Genetic","Evolution, Molecular","Models, Genetic","Animals","Selection, Genetic","Biological Evolution"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T22:05:07.206154Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}