{"doi":"10.1016/j.cub.2020.02.070","title":"Vision and Locomotion Combine to Drive Path Integration Sequences in Mouse Retrosplenial Cortex","abstract":null,"journal":"Current Biology","year":2020,"id":658629,"datarank":0.6456097639806255,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":0.0,"self_endowment_contribution":0.6456097639806255,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1243231,"name":"Leonardo A. Molina","orcid":"0000-0002-6601-7185","position":1,"is_corresponding":false},{"id":1639166,"name":"Vincent Bonin","orcid":"0000-0002-9437-8092","position":2,"is_corresponding":false},{"id":554007,"name":"Bruce L. McNaughton","orcid":"0000-0002-2080-5258","position":3,"is_corresponding":false},{"id":554257,"name":"Dun Mao","orcid":"0000-0001-5523-657X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Vision and Locomotion Combine to Drive Path Integration Sequences in Mouse Retrosplenial Cortex","abstract":"The retrosplenial cortex (RSC) is involved in a broad range of cognitive functions, integrating rich sensory, motor, and spatial signals from multiple brain areas, including the hippocampal system. RSC neurons show hippocampus-dependent activity reminiscent of place cell sequences. Using cellular calcium imaging in a virtual reality (VR)-based locomotion task, we investigate how the integration of visual and locomotor inputs may give rise to such activity in RSC. A substantial population shows neural sequences that track position in the VR environment. This activity is driven by the conjunction of visual stimuli sequences and active movement, which is suggestive of path integration. The activity is anchored to a reference point and predominantly follows the VR upon manipulations of optic flow against locomotion. Thus, locomotion-gated optic flow, combined with the presence of contextual cues at the start of each trial, is sufficient to drive the sequential activity. A subpopulation shows landmark-related visual responses that are modulated by animal's position in the VR. Thus, rather than fragmenting the spatial representation into equivalent locomotion-based ensemble versus optic-flow-based ensemble, in RSC, optic flow appears to override locomotion signals coherently in the population, when the gain between the two signals is altered.","is_dataset_classified":null,"base_score":4.304065093204169,"endowment":4.304065093204169,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32197086","pmcid":null,"openalex_id":"https://openalex.org/W3012556434","authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"-2017-03857","title":null},{"funder_name":"Canada Foundation for Innovation","grant_id":"33598","title":null},{"funder_name":"Fonds Wetenschappelijk Onderzoek","grant_id":"G0C1220N","title":null},{"funder_name":"Fonds Wetenschappelijk Onderzoek","grant_id":"G0D0516N","title":null},{"funder_name":"National Science Foundation","grant_id":"1631465","title":null},{"funder_name":"Onderzoeksraad, KU Leuven","grant_id":"C14/16/048","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"156040","title":null},{"funder_name":"Defense Advanced Research Projects Agency","grant_id":"0011-18-2-0021","title":null},{"funder_name":"CIHR","grant_id":"PJT 156040","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Alberta Innovates","grant_id":"","title":null}],"total_grants":11,"fwci":4.8673,"citation_percentile":0.96262501,"influential_citations":0,"citation_trend":[{"year":2020,"count":12},{"year":2021,"count":15},{"year":2022,"count":11},{"year":2023,"count":11},{"year":2024,"count":13},{"year":2025,"count":6},{"year":2026,"count":5}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S0960982220302773/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0960982220302773/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960982220302773?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960982220302773?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cub.2020.02.070","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32197086","host_type":"repository"},{"url":"https://lirias.kuleuven.be/bitstream/20.500.12942/712788/2/PIIS0960982220302773.pdf","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.cub.2020.02.070","host_type":""},{"url":"https://lirias.kuleuven.be/handle/20.500.12942/712788","host_type":""}],"fields_of_study":["Neural dynamics and brain function","Neuroscience and Neuropharmacology Research","Memory and Neural Mechanisms","0301 basic medicine","03 medical and health sciences","0302 clinical medicine","Animals","Gyrus Cinguli","Locomotion","Mice","Space Perception","Spatial Processing","Visual Perception"],"mesh_terms":["Animals","Gyrus Cinguli","Locomotion","Space Perception","Visual Perception","Mice","Spatial Processing"],"keywords":["Retrosplenial cortex","Biology","Neuroscience","Path integration","Path (computing)","Cortex (anatomy)","Cognitive science","Anatomy","Computational biology","Computer science","Locomotion","Optic flow","Self-motion","Reference Points","Visual Landmarks","Neural Sequences","Task Encoding","Life Sciences & Biomedicine - Other Topics","Biochemistry & Molecular Biology","MOTION","PLACE","RAT POSTERIOR CORTEX","HEAD-DIRECTION CELLS","Gyrus Cinguli","DARK","Mice","Spatial Processing","Animals","CONNECTIONS","11 Medical and Health Sciences","SPATIAL MEMORY","Science & Technology","31 Biological sciences","Cell Biology","32 Biomedical and clinical sciences","06 Biological Sciences","17 Psychology and Cognitive Sciences","52 Psychology","Space Perception","NAVIGATION","DISTANCE","HIPPOCAMPUS","Visual Perception","Life Sciences & Biomedicine","Developmental Biology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T04:51:21.982712Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}