{"doi":"10.1016/j.cub.2020.02.004","title":"Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex","abstract":"The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.","journal":"Current Biology","year":2020,"id":95200,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":473304,"name":"Riccardo Beltramo","orcid":"0000-0002-3125-2089","position":1,"is_corresponding":false},{"id":473305,"name":"Fabio Vallone","orcid":"0000-0001-8911-9611","position":2,"is_corresponding":false},{"id":473306,"name":"Ronan Chéreau","orcid":"0000-0002-2359-3086","position":3,"is_corresponding":false},{"id":328736,"name":"Angelo Forli","orcid":"0000-0002-0857-029X","position":4,"is_corresponding":false},{"id":397682,"name":"Manuel Molano‐Mazón","orcid":"0000-0002-9140-3571","position":5,"is_corresponding":false},{"id":473307,"name":"Tanika Bawa","orcid":"0000-0002-1368-0346","position":6,"is_corresponding":false},{"id":474234,"name":"Noemi Binini","orcid":null,"position":7,"is_corresponding":false},{"id":328735,"name":"Claudio Moretti","orcid":"0000-0003-3314-8936","position":8,"is_corresponding":false},{"id":473308,"name":"Anthony Holtmaat","orcid":"0000-0002-7577-0769","position":9,"is_corresponding":false},{"id":249867,"name":"Stefano Panzeri","orcid":"0000-0003-1700-8909","position":10,"is_corresponding":false},{"id":328740,"name":"Tommaso Fellin","orcid":"0000-0003-2718-7533","position":11,"is_corresponding":false},{"id":328737,"name":"Dania Vecchia","orcid":"0000-0002-6091-538X","position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-18T22:33:30.364261Z","pmid":"32169206","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}