{"doi":"10.1016/j.cub.2009.12.045","title":"A Role for Separase in the Regulation of RAB-11-Positive Vesicles at the Cleavage Furrow and Midbody","abstract":null,"journal":"Current Biology","year":2010,"id":593021,"datarank":1.828495702030567,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":1.2358091442433528,"self_endowment_contribution":0.5926865577872142,"citer_contribution":1.2358091442433528,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":37,"citers_with_citation_signal":31,"citers_with_endowment":31,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":203301,"name":"John G. White","orcid":null,"position":1,"is_corresponding":false},{"id":474094,"name":"Yixian Zheng","orcid":null,"position":2,"is_corresponding":false},{"id":203840,"name":"Joshua N. Bembenek","orcid":"0000-0002-0966-2268","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody.","abstract":"Cell division requires coordinated regulation of chromosome segregation and cytokinesis. Although much is known about the function of the protease separase in promoting sister chromosome separation, the role of separase during cytokinesis is unclear. We show that separase localizes to the ingressing furrow and midbody during cytokinesis in the C. elegans embryo. Loss of separase function during the early mitotic divisions causes cytokinesis failure that is not due to eggshell defects or chromosome nondisjunction. Moreover, depletion of separase causes the accumulation of RAB-11-positive vesicles at the cleavage furrow and midbody that is not a consequence of chromosome nondisjunction, but is mimicked by depletion of vesicle fusion machinery. Collectively, these data indicate that separase is required for cytokinesis by regulating the incorporation of RAB-11-positive vesicles into the plasma membrane at the cleavage furrow and midbody.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20116245","pmcid":"PMC2833016","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"RO1 GM56312","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"5F32 GM076867-02","title":"The Role of Separase During Cytokinesis in C elegans"},{"funder_name":"NIGMS NIH HHS","grant_id":"F32 GM076867","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM56312","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM7583","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S0960982209022088/pdf","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2833016","host_type":"repository"},{"url":"https://doi.org/10.1016/j.cub.2009.12.045","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/20116245","host_type":""},{"url":"http://dx.doi.org/10.1016/j.cub.2009.12.045","host_type":""},{"url":"https://dx.doi.org/10.1016/j.cub.2009.12.045","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Animals, Genetically Modified","Caenorhabditis elegans","rab GTP-Binding Proteins","Caenorhabditis elegans Proteins","Recombinant Fusion Proteins","Chromosome Segregation","Cytokinesis","Separase","rab11 GTP-Binding Proteins"],"keywords":["Agricultural and Biological Sciences(all)","Biochemistry, Genetics and Molecular Biology(all)","Recombinant Fusion Proteins","Animals, Genetically Modified","rab GTP-Binding Proteins","Chromosome Segregation","Animals","CELLBIO","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Separase","Cytokinesis","rab11 GTP-Binding Proteins"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T16:42:19.098948Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}