{"doi":"10.1016/j.cub.2008.08.061","title":"A Role for Very-Long-Chain Fatty Acids in Furrow Ingression during Cytokinesis in Drosophila Spermatocytes","abstract":null,"journal":"Current Biology","year":2008,"id":633996,"datarank":0.7077748306942643,"base_score":4.718498871295094,"endowment":4.718498871295094,"self_citation_contribution":0.7077748306942643,"citation_network_contribution":0.0,"self_endowment_contribution":0.7077748306942643,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":111,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":819972,"name":"Maria Grazia Giansanti","orcid":"0000-0002-6753-7262","position":1,"is_corresponding":false},{"id":519452,"name":"Ryuichi Nishihama","orcid":"0000-0002-7032-732X","position":2,"is_corresponding":false},{"id":838956,"name":"Benjamin Bolival","orcid":"0000-0001-5734-5112","position":3,"is_corresponding":false},{"id":1644073,"name":"John Pringle","orcid":null,"position":4,"is_corresponding":false},{"id":351458,"name":"Maurizio Gatti","orcid":"0000-0003-3777-300X","position":5,"is_corresponding":false},{"id":551884,"name":"Margaret T. Fuller","orcid":"0000-0002-3804-4987","position":6,"is_corresponding":false},{"id":1036605,"name":"Edith Szafer-Glusman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Role for Very-Long-Chain Fatty Acids in Furrow Ingression during Cytokinesis in Drosophila Spermatocytes","abstract":"Cell shape and membrane remodeling rely on regulated interactions between the lipid bilayer and cytoskeletal arrays at the cell cortex. During cytokinesis, animal cells build an actomyosin ring anchored to the plasma membrane at the equatorial cortex. Ring constriction coupled to plasma-membrane ingression separates the two daughter cells. Plasma-membrane lipids influence membrane biophysical properties such as membrane curvature and elasticity and play an active role in cell function, and specialized membrane domains are emerging as important factors in regulating assembly and rearrangement of the cytoskeleton. Here, we show that mutations in the gene bond, which encodes a Drosophila member of the family of Elovl proteins that mediate elongation of very-long-chain fatty acids, block or dramatically slow cleavage-furrow ingression during early telophase in dividing spermatocytes. In bond mutant cells at late stages of division, the contractile ring frequently detaches from the cortex and constricts or collapses to one side of the cell, and the cleavage furrow regresses. Our findings implicate very-long-chain fatty acids or their derivative complex lipids in allowing supple membrane deformation and the stable connection of cortical contractile components to the plasma membrane during cell division.","is_dataset_classified":null,"base_score":4.718498871295094,"endowment":4.718498871295094,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18804373","pmcid":"PMC2577570","openalex_id":"https://openalex.org/W2107059489","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"GM31006","title":null},{"funder_name":"National Institutes of Health","grant_id":"GM62276","title":null},{"funder_name":"American Heart Association","grant_id":"0525061Y","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R37 GM031006","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM062276","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM031006","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM031006-16","title":"GENETIC STUDY OF THE YEAST CELL CYCLE"}],"total_grants":7,"fwci":4.2855,"citation_percentile":0.94237485,"influential_citations":0,"citation_trend":[{"year":2012,"count":12},{"year":2013,"count":6},{"year":2014,"count":2},{"year":2015,"count":6},{"year":2016,"count":5},{"year":2017,"count":3},{"year":2018,"count":10},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":8},{"year":2022,"count":4},{"year":2023,"count":9},{"year":2024,"count":10},{"year":2025,"count":2},{"year":2026,"count":5}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S0960982208011846/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0960982208011846/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960982208011846?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960982208011846?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cub.2008.08.061","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18804373","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2577570","host_type":"repository"},{"url":"http://hdl.handle.net/11573/10017","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.cub.2008.08.061","host_type":""},{"url":"https://publications.cnr.it/doc/11610","host_type":""},{"url":"https://dx.doi.org/10.1016/j.cub.2008.08.061","host_type":""},{"url":"http://www.cnr.it/prodotto/i/11610","host_type":""},{"url":"https://hdl.handle.net/20.500.14243/168460","host_type":""},{"url":"https://hdl.handle.net/11573/10017","host_type":""},{"url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000259523600030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","host_type":""}],"fields_of_study":["Lipid metabolism and biosynthesis","Sperm and Testicular Function","Neurobiology and Insect Physiology Research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Amino Acid Sequence","Animals","Base Pairing","Cytoskeleton","Drosophila","Drosophila Proteins","Fatty Acids","Lipid Bilayers","Male","Membrane Lipids","Membrane Proteins","Molecular Sequence Data","Spermatocytes","Spindle Apparatus"],"mesh_terms":["Amino Acid Sequence","Animals","Cytoskeleton","Drosophila","Fatty Acids","Lipid Bilayers","Male","Membrane Lipids","Membrane Proteins","Spindle Apparatus","Molecular Sequence Data","Spermatocytes","Base Pairing","Drosophila Proteins"],"keywords":["Biology","Ingression","Cytokinesis","Drosophila (subgenus)","Cell biology","Genetics","Cell","Gene","Cell division","Male","Agricultural and Biological Sciences(all)","Biochemistry, Genetics and Molecular Biology(all)","Fatty Acids","Lipid Bilayers","Molecular Sequence Data","MYOSIN-II","Membrane Proteins","CELLCYCLE","Spindle Apparatus","Membrane Lipids","ANIMAL CYTOKINESIS","MEMBRANE DOMAINS","Spermatocytes","Animals","Drosophila Proteins","Drosophila","Amino Acid Sequence","Base Pairing","Cytoskeleton"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T12:59:23.752635Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}