{"doi":"10.1016/j.ctro.2021.11.003","title":"Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients [PIRATES]: A Phase I safety and feasibility trial of MRI-guided adaptive particle radiotherapy","abstract":"INTRODUCTION: Radiation dose-escalation for head and neck cancer (HNC) patients aiming to improve cure rates is challenging due to the increased risk of unacceptable treatment-induced toxicities. With \"Proton Image-guided Radiation Assignment for Therapeutic Escalation via Selection of locally advanced head and neck cancer patients\" (PIRATES), we present a novel treatment approach that is designed to facilitate dose-escalation while minimizing the risk of dose-limiting toxicities for locally advanced HPV-negative HNC patients. The aim of this Phase I trial is to assess the safety & feasibility of PIRATES approach. METHODS: grade 3 toxicity occurring in 3-6 months after radiation. DISCUSSION: the high dose tumor volume with hybrid hyper-fractionation and not boosting mucosal and bone tissues. Ultimately, if successful, PIRATES has the potential to safety increase local control rates in HNC patients with high loco-regional failure risk.Trial registration: ClinicalTrials.gov ID: NCT04870840; Registration date: May 4, 2021.Netherlands Trial Register ID: NL9603; Registration date: July 15, 2021.","journal":"Clinical and Translational Radiation Oncology","year":2021,"id":195850,"datarank":0.5306419273119526,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.20105824071151962,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.20105824071151962,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04870840"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":348525,"name":"Steven J. Frank","orcid":"0000-0001-6517-7884","position":1,"is_corresponding":false},{"id":268557,"name":"Ying Yuan","orcid":"0000-0003-3163-480X","position":2,"is_corresponding":false},{"id":768452,"name":"Brandon Gunn","orcid":null,"position":3,"is_corresponding":false},{"id":346829,"name":"Amy C. Moreno","orcid":"0000-0001-6762-6807","position":4,"is_corresponding":false},{"id":351182,"name":"Abdallah Mohamed","orcid":"0000-0003-2064-7613","position":5,"is_corresponding":false},{"id":767781,"name":"Kathryn Preston","orcid":"0000-0001-7193-5338","position":6,"is_corresponding":false},{"id":767782,"name":"Yun Qing","orcid":"0009-0002-7320-2992","position":7,"is_corresponding":false},{"id":258979,"name":"Michael T. Spiotto","orcid":"0000-0003-4484-462X","position":8,"is_corresponding":false},{"id":351188,"name":"William H. Morrison","orcid":"0000-0002-9546-0805","position":9,"is_corresponding":false},{"id":293157,"name":"Anna Lee","orcid":"0000-0002-9114-1815","position":10,"is_corresponding":false},{"id":351187,"name":"Jack Phan","orcid":"0000-0001-5977-6004","position":11,"is_corresponding":false},{"id":299194,"name":"Adam S. Garden","orcid":"0000-0001-7926-2641","position":12,"is_corresponding":false},{"id":32353,"name":"David I. Rosenthal","orcid":"0000-0001-7124-7447","position":13,"is_corresponding":false},{"id":587161,"name":"Johannes A. Langendijk","orcid":"0000-0003-1083-372X","position":14,"is_corresponding":false},{"id":295555,"name":"Clifton D. Fuller","orcid":"0000-0002-5264-3994","position":15,"is_corresponding":false},{"id":103919,"name":"Lisanne V. van Dijk","orcid":"0000-0002-9515-5616","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:50:11.609550Z","pmid":"34841093","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}