{"doi":"10.1016/j.ctim.2021.102722","title":"A pilot study of the acceptability, feasibility and safety of yoga for chronic pain in sickle cell disease","abstract":"OBJECTIVES: To determine the acceptability, feasibility and safety of yoga for chronic pain in sickle cell disease. DESIGN AND SETTING: In Part A of this two-part study, adolescents with SCD and chronic pain (Group 1) and their parent (Group 2) completed a survey designed to capture pain characteristics, attitudes and practices related to yoga, and potential acceptability of a yoga program. In Part B, the study assessed the feasibility and safety of an instructor-led group yoga program. The study was registered on clinicaltrials.gov (NCT03694548). INTERVENTION: Eight instructor-led group yoga sessions. MAIN OUTCOME MEASURES: Feasibility and safety outcomes were chosen a priori, as follows: 1) Proportion of adolescent patients with SCD and chronic pain approached that consent to participate in Part A, 2) Proportion of adolescent participants enrolled in Part A that consent to participate in Part B, 3) Proportion of participants enrolled in Part B that attend at least 6 of 8 yoga sessions, 4) Proportion of participants enrolled in Part B with an ED visit or a hospitalization for pain within 24 h of completion of each yoga session, 5) Proportion of participants in Part B who complete all study assessments before, and at the end of the yoga program, 6) Adherence to submission of pain diary. RESULTS: The median age of 15 patient participants in Part A was 16 (IQR 14-17), and 14 parents was 43.5 (IQR 42-51). Most participants were female. Most participant responses indicated a positive opinion of yoga. Nine adolescents (60 %) from Part A participated in Part B of the study. The median age of 9 participants in Part B was 17 (IQR 15-18), and 5 of the 9 participants were female (53.3 %). Only one participant was able to attend 3 of the 8 yoga sessions offered, and did not experience any ED visits or hospitalizations following the yoga sessions. None of the other feasibility endpoints were met in this study. CONCLUSIONS: Patients with SCD and chronic pain overall have a positive opinion of yoga, but there are challenges with recruitment and retention of participants in a clinical trial of yoga, and barriers to feasibility of an in-person group yoga intervention.","journal":"Complementary Therapies in Medicine","year":2021,"id":188345,"datarank":0.7071820847506297,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.28220008314219724,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.28220008314219724,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":12,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8445,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03694548"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":750206,"name":"Anthony Cooley","orcid":null,"position":1,"is_corresponding":false},{"id":380281,"name":"Diana Ross","orcid":"0000-0001-7383-9710","position":2,"is_corresponding":false},{"id":749265,"name":"Lauren Hawkins","orcid":"0000-0003-0786-8892","position":3,"is_corresponding":false},{"id":749266,"name":"Marlysa Sullivan","orcid":"0000-0003-4043-7998","position":4,"is_corresponding":false},{"id":749267,"name":"Rachel Astles","orcid":"0000-0002-7044-1202","position":5,"is_corresponding":false},{"id":380280,"name":"Cynthia Sinha","orcid":"0000-0002-4920-9521","position":6,"is_corresponding":false},{"id":473694,"name":"Deeksha Katoch","orcid":"0000-0003-3646-5523","position":7,"is_corresponding":false},{"id":750207,"name":"Manasa Peddineni","orcid":null,"position":8,"is_corresponding":false},{"id":732888,"name":"Beatrice E. Gee","orcid":"0000-0003-0233-0321","position":9,"is_corresponding":false},{"id":333558,"name":"Peter A. Lane","orcid":"0000-0001-5887-6222","position":10,"is_corresponding":false},{"id":380283,"name":"Lakshmanan Krishnamurti","orcid":"0000-0003-3242-0037","position":11,"is_corresponding":false},{"id":380284,"name":"Nitya Bakshi","orcid":"0000-0002-0876-9506","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T23:49:10.350554Z","pmid":"33892094","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}