{"doi":"10.1016/j.ctarc.2021.100503","title":"Association of smoking with anal high-risk HPV infection and histologically confirmed anal high-grade squamous intraepithelial lesions among a clinic-based population in Puerto Rico","abstract":"INTRODUCTION: Current smoking is a risk factor for anal cancer. Yet, its association with anal human papillomavirus infection (HPV) and anal high-grade squamous intraepithelial lesions (HSIL) remains unclear. We assessed the association of smoking with 1) anal high-risk HPV (HR-HPV) infection and 2) anal HSIL. METHODS: Data from the baseline visit of patients from the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Cancer Center (May 2015- June 2021) was analyzed. Patients were eligible if they had information on smoking status, complete high-resolution anoscopy (HRA) with biopsy, and HR-HPV testing (n = 427). Logistic regression models estimated the odds ratio (OR) with 95% confidence intervals (CIs) adjusting for covariates. RESULTS: Mean age was 44 ± 13 years, 69% were men, 74% were HIV-infected, and 25% reported being current smokers. 74% had anal HR-HPV infection. HSIL was diagnosed in 40% of patients. Current smokers had significantly higher odds (OR: 1.71, 95% CI: 1.04-2.82) of having HSIL compared to non-smokers after adjusting for age, sexual risk group, lifetime number of sexual partners, HIV status, and HR-HPV infection. Smoking was not associated with HR-HPV infection (OR: 1.56, 95% CI: 0.83-2.95) after adjusting for age, sexual risk group, lifetime number of sexual partners, and HIV status. CONCLUSIONS: Current smoking was associated with histologically confirmed HSIL but not with HR-HPV infection among this high-risk Hispanic population. Results highlight the need to explore targeted smoking cessation campaigns among populations at higher risk of developing HSIL, as an anal cancer prevention strategy.","journal":"Cancer Treatment and Research Communications","year":2021,"id":192570,"datarank":0.6656700595164549,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.28092765589722435,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.28092765589722435,"corpus_percentile":70.01624506846136,"corpus_rank":3877,"citation_count":12,"citer_count":7,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6006,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":759712,"name":"Jeslie M. Ramos‐Cartagena","orcid":"0000-0001-8024-1346","position":1,"is_corresponding":false},{"id":759713,"name":"Humberto M. Guiot","orcid":"0000-0001-5177-977X","position":2,"is_corresponding":false},{"id":760327,"name":"Cristina Muñoz","orcid":null,"position":3,"is_corresponding":false},{"id":760328,"name":"Yolanda Rodríguez","orcid":null,"position":4,"is_corresponding":false},{"id":463913,"name":"Vivian Colón‐López","orcid":"0000-0002-0008-1539","position":5,"is_corresponding":false},{"id":307925,"name":"Ashish A. Deshmukh","orcid":"0000-0001-8936-8108","position":6,"is_corresponding":false},{"id":537020,"name":"Maribel Tírado-Gómez","orcid":null,"position":7,"is_corresponding":false},{"id":589450,"name":"Ana P. Ortíz","orcid":"0000-0003-1017-9473","position":8,"is_corresponding":false},{"id":760326,"name":"Kandyce G. Keller","orcid":null,"position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T23:49:43.496702Z","pmid":"34999478","pmcid":"PMC9253704","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}