{"doi":"10.1016/j.crphys.2025.100171","title":"Effects of short-term sleep reduction and aerobic exercise on metabolism and inflammation in healthy adults","abstract":null,"journal":"Current Research in Physiology","year":2025,"id":628195,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1626351,"name":"Jocelyn Kaveney","orcid":null,"position":1,"is_corresponding":false},{"id":1626352,"name":"Eric Lessard","orcid":null,"position":2,"is_corresponding":false},{"id":1626353,"name":"Braden Wilson","orcid":null,"position":3,"is_corresponding":false},{"id":1250256,"name":"Graham R. McGinnis","orcid":"0000-0001-6185-6505","position":4,"is_corresponding":false},{"id":778510,"name":"Ryan K. Perkins","orcid":"0000-0002-2546-4085","position":5,"is_corresponding":false},{"id":1626350,"name":"Gracie L. Dupuis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of short-term sleep reduction and aerobic exercise on metabolism and inflammation in healthy adults","abstract":"max after 7 nights of habitual sleep (CON) and then 7 nights of sleep reduction (SR) (i.e., sleeping ∼3 h less per night). Carbohydrate and fat oxidation rate, and energy expenditure were assessed via indirect calorimetry. Soluble TLR4 (sTLR4) and IL6 in the blood was assessed via ELISA. Results show sleep was reduced 31 % (p ≤ 0.05) during the SR period (CON: 8.1 ± 0.3 h/night; SR: 5.4 ± 0.2 h/night). Sleep efficiency increased (+5 ± 2 %), while average number of awakenings (-42 ± 4 %) and sleep fragmentation index (-24 ± 8 %) decreased in SR (all p ≤ 0.05). SR increased resting carbohydrate oxidation (+45 ± 1 %), kcals from carbohydrates (+45 ± 1 %), and total kcal utilization (+23 ± 0 %) compared to CON (all p ≤ 0.05). Seated resting heart rate increased 5 ± 0 % (p ≤ 0.05), while mean arterial pressure decreased 3 ± 0 % (p ≤ 0.05) following SR. Resting circulating sTLR4 and IL6 remained unchanged following SR (p > 0.05). IL6 increased significantly after AE in both CON (+161 ± 68 %) and SR (+133 ± 37 %), with no difference between groups, while sTLR4 remained unchanged (p > 0.05). Metabolic and cardiovascular responses during exercise were not different between CON and SR (p > 0.05). Average RPE during AE was higher in SR than CON (+3 ± 0 %, p ≤ 0.05). These findings show that short-term sleep reduction influences resting metabolic and cardiovascular function.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41424685","pmcid":"PMC12717562","openalex_id":"https://openalex.org/W4415752561","authors":[],"funders":[],"total_grants":0,"fwci":1.2611,"citation_percentile":0.84078898,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.crphys.2025.100171","host_type":"journal"},{"url":"https://doi.org/10.1016/j.crphys.2025.100171","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2665944125000331?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2665944125000331?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41424685","host_type":"repository"},{"url":"https://doaj.org/article/f98a44d7e71b4628b294f87ab1b4d15c","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12717562/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12717562","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12717562?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Sleep and related disorders","Cardiovascular and exercise physiology","Obstructive Sleep Apnea Research"],"mesh_terms":[],"keywords":["Sleep (system call)","Aerobic exercise","Blood pressure","Heart rate","Carbohydrate metabolism","Anaerobic exercise","Carbohydrate","Circadian rhythm","Physical exercise","Metabolism","Inflammation","Sleep Reduction","Stlr4"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T11:45:31.410653Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}