{"doi":"10.1016/j.crmeth.2022.100234","title":"Rapid detection of an Ebola biomarker with optical microring resonators","abstract":"Ebola virus (EBOV) is a highly infectious pathogen, with a case mortality rate as high as 89%. Rapid therapeutic treatments and supportive measures can drastically improve patient outcome; however, the symptoms of EBOV disease (EVD) lack specificity from other endemic diseases. Given the high mortality and significant symptom overlap, there is a critical need for sensitive, rapid diagnostics for EVD. Facile diagnosis of EVD remains a challenge. Here, we describe a rapid and sensitive diagnostic for EVD through microring resonator sensors in conjunction with a unique biomarker of EBOV infection, soluble glycoprotein (sGP). Microring resonator sensors detected sGP in under 40 min with a limit of detection (LOD) as low as 1.00 ng/mL in serum. Furthermore, we validated our assay with the detection of sGP in serum from EBOV-infected non-human primates. Our results demonstrate the utility of a high-sensitivity diagnostic platform for detection of sGP for diagnosis of EVD.","journal":"Cell Reports Methods","year":2022,"id":251269,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":894097,"name":"Krista Meserve","orcid":"0000-0002-9398-9158","position":1,"is_corresponding":false},{"id":441735,"name":"M. Javad Aman","orcid":"0000-0001-6977-4707","position":2,"is_corresponding":false},{"id":894606,"name":"Hong Vu","orcid":null,"position":3,"is_corresponding":false},{"id":325141,"name":"Larry Zeitlin","orcid":"0000-0002-6857-1024","position":4,"is_corresponding":false},{"id":109549,"name":"John M. Dye","orcid":"0000-0002-0883-5016","position":5,"is_corresponding":false},{"id":410248,"name":"Jeffrey W. Froude","orcid":null,"position":6,"is_corresponding":false},{"id":328258,"name":"Daisy W. Leung","orcid":"0000-0002-7189-9557","position":7,"is_corresponding":false},{"id":367271,"name":"Lan Yang","orcid":"0000-0002-9052-0450","position":8,"is_corresponding":false},{"id":441734,"name":"Frederick W. Holtsberg","orcid":"0000-0001-5530-9943","position":9,"is_corresponding":false},{"id":341256,"name":"Ryan C. Bailey","orcid":"0000-0003-1021-4267","position":10,"is_corresponding":false},{"id":227340,"name":"Gaya K. Amarasinghe","orcid":"0000-0002-0418-9707","position":11,"is_corresponding":false},{"id":555567,"name":"Abraham J. Qavi","orcid":"0000-0002-9349-2600","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T00:24:37.429628Z","pmid":"35784644","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}