{"doi":"10.1016/j.crmeth.2021.100087","title":"Computational tools for analyzing single-cell data in pluripotent cell differentiation studies","abstract":"Single-cell technologies are revolutionizing the ability of researchers to infer the causes and results of biological processes. Although several studies of pluripotent cell differentiation have recently utilized single-cell sequencing data, other aspects related to the optimization of differentiation protocols, their validation, robustness, and usage are still not taking full advantage of single-cell technologies. In this review, we focus on computational approaches for the analysis of single-cell omics and imaging data and discuss their use to address many of the major challenges involved in the development, validation, and use of cells obtained from pluripotent cell differentiation.","journal":"Cell Reports Methods","year":2021,"id":193329,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9411,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":519148,"name":"Amir Alavi","orcid":"0000-0002-2868-0904","position":1,"is_corresponding":false},{"id":279408,"name":"Mo R. Ebrahimkhani","orcid":"0000-0001-5753-6779","position":2,"is_corresponding":false},{"id":247212,"name":"Ziv Bar‐Joseph","orcid":"0000-0003-3430-6051","position":3,"is_corresponding":false},{"id":254889,"name":"Jun Ding","orcid":"0000-0001-5183-6885","position":0,"is_corresponding":true}],"reference_count":139,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:49:51.300073Z","pmid":"35474899","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}