{"doi":"10.1016/j.crmeth.2021.100053","title":"Toward reproducible, scalable, and robust data analysis across multiplex tissue imaging platforms","abstract":"The emergence of megascale single-cell multiplex tissue imaging (MTI) datasets necessitates reproducible, scalable, and robust tools for cell phenotyping and spatial analysis. We developed open-source, graphics processing unit (GPU)-accelerated tools for intensity normalization, phenotyping, and microenvironment characterization. We deploy the toolkit on a human breast cancer (BC) tissue microarray stained by cyclic immunofluorescence and present the first cross-validation of breast cancer cell phenotypes derived by using two different MTI platforms. Finally, we demonstrate an integrative phenotypic and spatial analysis revealing BC subtype-specific features.","journal":"Cell Reports Methods","year":2021,"id":165845,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9348,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":645766,"name":"Jennifer Eng","orcid":"0000-0003-1499-8417","position":1,"is_corresponding":false},{"id":305759,"name":"Guillaume Thibault","orcid":"0000-0002-0734-2041","position":2,"is_corresponding":false},{"id":225142,"name":"Koei Chin","orcid":"0000-0001-8061-7462","position":3,"is_corresponding":false},{"id":225103,"name":"Joe W. Gray","orcid":"0000-0001-9225-6756","position":4,"is_corresponding":false},{"id":225135,"name":"Young Hwan Chang","orcid":"0000-0001-8764-1959","position":5,"is_corresponding":false},{"id":225131,"name":"Erik A. Burlingame","orcid":"0000-0002-7309-9350","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T23:45:40.838485Z","pmid":"34485971","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}