{"doi":"10.1016/j.critrevonc.2026.105259","title":"Fatty acid metabolic reprogramming in gastrointestinal tumor microenvironment: Emerging mechanisms and therapeutic opportunities","abstract":null,"journal":"Critical Reviews in Oncology/Hematology","year":2026,"id":673466,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1759549,"name":"Yuhan Shen","orcid":null,"position":1,"is_corresponding":false},{"id":1759552,"name":"Xingyan Lv","orcid":null,"position":2,"is_corresponding":false},{"id":1472377,"name":"Jiaxin Tian","orcid":null,"position":3,"is_corresponding":false},{"id":1759553,"name":"Xiaoshuo Dai","orcid":null,"position":4,"is_corresponding":false},{"id":489203,"name":"Jing Lu","orcid":"0000-0002-7559-6123","position":5,"is_corresponding":false},{"id":1759547,"name":"Xiangdi Sun","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Fatty acid metabolic reprogramming in gastrointestinal tumor microenvironment: Emerging mechanisms and therapeutic opportunities","abstract":"Gastrointestinal (GI) tumors, characterized by high incidence and mortality rates, represent a major global health challenge. Metabolic reprogramming has been recognized as one of their defining hallmarks. Beyond aberrant glucose metabolism, accumulating evidence has revealed how dysregulated fatty acid (FA) metabolism plays a multifaceted role in regulating the tumor microenvironment (TME). By modulating tumor, immune, and stromal cells, FA metabolism profoundly influences tumorigenesis, progression, and cell death. Despite advances in current treatments, the inherent immunosuppressive nature of TME and the therapeutic resistance of tumor cells still remain major obstacles. Notably, targeting key nodes of FA metabolism has emerged as a promising strategy to overcome these challenges. Thus, in this review, we systematically delineate how FA metabolic reprogramming shapes the GI tumor microenvironment by regulating tumor, immune, and stromal cells in multiple ways. Furthermore, we critically explore the translational potential of FA metabolism in biomarker development, targeted therapy, and combination therapeutic strategies. By synthesizing these insights, this review aims to provide forward-looking perspectives on future therapeutic strategies against GI tumors.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41802688","pmcid":null,"openalex_id":"https://openalex.org/W7134189620","authors":[],"funders":[],"total_grants":0,"fwci":7.1166,"citation_percentile":0.95428393,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.critrevonc.2026.105259","host_type":"journal"},{"url":"https://doi.org/10.1016/j.critrevonc.2026.105259","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1040842826001460?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1040842826001460?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41802688","host_type":"repository"}],"fields_of_study":["Cancer, Lipids, and Metabolism","Cancer, Hypoxia, and Metabolism","Cancer Research and Treatments"],"mesh_terms":["Metabolic Reprogramming","Animals","Antineoplastic Combined Chemotherapy Protocols","Fatty Acids","Gastrointestinal Neoplasms","Humans","Immunotherapy","Prognosis","Biomarkers, Tumor","Signal Transduction","Gene Expression Regulation, Neoplastic","Drug Resistance, Neoplasm","Precision Medicine","Molecular Targeted Therapy","Tumor Microenvironment"],"keywords":["Tumor microenvironment","Stromal cell","Immune system","Reprogramming","Immunotherapy","Cell metabolism","Fatty acid metabolism","Metabolic pathway","Fatty acid","Metabolic Reprogramming","Gastrointestinal Tumor","Combined Therapeutic Strategies"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T13:29:58.814791Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}