{"doi":"10.1016/j.critrevonc.2017.02.021","title":"Potential application and prevalence of the CD30 (Ki-1) antigen among solid tumors: A focus review of the literature","abstract":null,"journal":"Critical Reviews in Oncology/Hematology","year":2017,"id":602273,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1544527,"name":"Kevin Gee","orcid":null,"position":1,"is_corresponding":false},{"id":1544529,"name":"Cassandra Votruba","orcid":null,"position":2,"is_corresponding":false},{"id":1006933,"name":"Ali McBride","orcid":"0000-0002-9430-4675","position":3,"is_corresponding":false},{"id":336350,"name":"Faiz Anwer","orcid":"0000-0001-6914-7439","position":4,"is_corresponding":false},{"id":713111,"name":"Garrett K. Berger","orcid":"0000-0001-8389-0691","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Potential application and prevalence of the CD30 (Ki-1) antigen among solid tumors: A focus review of the literature","abstract":"<h4>Background</h4>CD30 (Ki-1) is a cell membrane protein derived from the tumor necrosis factor (TNF) receptor family. The CD30 antigen has been associated primarily with Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL). Brentuximab vedotin (BV) is an antibody-drug conjugate targeting the CD30 antigen. FDA approval for BV includes relapsed and refractory HL and sALCL. The CD30 antigen also has been identified in many solid tumors, predominantly of germ cell origins and early clinical data is promising.<h4>Objective</h4>Perform a focus literature review evaluating the prevalence of the CD30 antigen among nonlymphomatous tumors with a potential correlate for CD30 targeted therapy.<h4>Eligibility criteria</h4>Inclusion criteria: all retrospective reviews and case reports citing CD30 positivity or negativity in non-lymphomatous malignancies in which data were presented based on location.<h4>Exclusion criteria</h4>studies with hematopoetic malignancies, cutaneous malignancies, non-human populations, and non-english publications.<h4>Included studies</h4>A total of 119 articles met these criteria and are summarized in this manuscript.<h4>Conclusion</h4>The CD30 antigen has shown variable prevalence among non-hematopoetic tumors, most notably among germ cell tumors and mesothelioma. With additional, preclinical and properly powered clinical studies, CD30 targeted therapy such as that of BV, alone or in combination with other agents may prove to be a strong candidate in the treatment of various CD30<sup>+</sup> malignancies.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28427526","pmcid":null,"openalex_id":"https://openalex.org/W2593797152","authors":[],"funders":[],"total_grants":0,"fwci":2.0913,"citation_percentile":0.86344538,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1040842816303274?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1040842816303274?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.critrevonc.2017.02.021","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28427526","host_type":"repository"}],"fields_of_study":["Cutaneous lymphoproliferative disorders research","Lymphoma Diagnosis and Treatment","Nonmelanoma Skin Cancer Studies","Antineoplastic Agents","Brentuximab Vedotin","Humans","Immunoconjugates","Immunotherapy","Ki-1 Antigen","Neoplasms"],"mesh_terms":["Brentuximab Vedotin","Antineoplastic Agents","Humans","Immunotherapy","Neoplasms","Ki-1 Antigen","Immunoconjugates"],"keywords":["CD30","Brentuximab vedotin","Medicine","Antibody-drug conjugate","Oncology","Antigen","Lymphoma","Anaplastic large-cell lymphoma","Germ cell tumors","Immunology","Internal medicine","Cancer research","Pathology","Antibody","Chemotherapy","Monoclonal antibody","Solid tumor","Antibody-drug-conjugate","Ki-1","Non-hematopoetic","Non-lymphomatous"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T18:52:46.188267Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}