{"doi":"10.1016/j.copbio.2025.103264","title":"Biocomputing at the crossroad between emulating artificial intelligence and cellular supremacy","abstract":null,"journal":"Current Opinion in Biotechnology","year":2025,"id":641026,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1666378,"name":"Lingyun Zhu","orcid":null,"position":1,"is_corresponding":false},{"id":486386,"name":"Hui Wang","orcid":"0000-0002-0011-8899","position":2,"is_corresponding":false},{"id":1666381,"name":"Mingqi Xie","orcid":"0000-0001-5657-532X","position":3,"is_corresponding":false},{"id":1666376,"name":"Xinyuan Qiu","orcid":"0000-0002-9662-8075","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biocomputing at the crossroad between emulating artificial intelligence and cellular supremacy","abstract":"Biocomputation aims to create sophisticated biological systems capable of addressing important problems in (bio)medicine with a machine-like precision. At present, computational gene networks engineered by single- or multi-layered assembly of DNA-, RNA- and protein-level gene switches have allowed bacterial or mammalian cells to perform various regulation logics of interest, including Boolean calculation or neural network–like computing. This review highlights the molecular building blocks, design principles, and computational tasks demonstrated by current biocomputers, before briefly discussing possible fields where biological computers may ultimately outcompete their electronic counterparts and achieve cellular supremacy. • Biocomputation refers to regulation of gene expression with machine-like precision. • Computational networks can comprise single or multiple layers of regulation stages. • Increased complexity may result from larger sets of orthogonal regulatory tools. • Biocomputers are already providing solutions for diagnostics and cell-based therapy.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39837198","pmcid":null,"openalex_id":"https://openalex.org/W4406633326","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"32071429","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32471479","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32371498","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32400989","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82403872","title":null},{"funder_name":"Ministry of Science and Technology of the People's Republic of China","grant_id":"2023YFF1205400","title":null},{"funder_name":"Ministry of Science and Technology of the People's Republic of China","grant_id":"2020YFA0909200","title":null},{"funder_name":"Ministry of Science and Technology of the People's Republic of China","grant_id":"","title":null}],"total_grants":8,"fwci":5.7475,"citation_percentile":0.95389699,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.copbio.2025.103264","host_type":"journal"},{"url":"https://doi.org/10.1016/j.copbio.2025.103264","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0958166925000084?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0958166925000084?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39837198","host_type":"repository"}],"fields_of_study":["Cell Image Analysis Techniques","Gene Regulatory Network Analysis","Artificial Intelligence","Computational Biology","Humans","Gene Regulatory Networks","Animals"],"mesh_terms":["Animals","Artificial Intelligence","Humans","Neural Networks, Computer","Computational Biology","Gene Regulatory Networks"],"keywords":["Artificial intelligence","Computer science"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T15:28:04.194408Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}