{"doi":"10.1016/j.conctc.2020.100531","title":"The Integrative Migraine Pain Alleviation through Chiropractic Therapy (IMPACT) trial: Study rationale, design and intervention validation","abstract":"INTRODUCTION: Approximately 15% of the US population experiences migraine, with women afflicted three times as often as men. While medications are often used as first-line treatments, up to 50% of people with migraine pursue complementary and integrative medicine. One promising non-pharmacological approach for migraine is chiropractic care, due to the co-occurrence of migraine disease and musculoskeletal tension and pain. To date, no large-scale trials have evaluated the impact of a comprehensive model of chiropractic care on migraine. METHODS: The Integrative Migraine Pain Alleviation through Chiropractic Therapy (IMPACT) study is a two-arm pilot pragmatic randomized clinical trial evaluating a multimodal chiropractic care intervention plus enhanced usual care (UC) vs. enhanced UC alone for adult women with episodic migraine. A total of 60 women aged 20-55 who meet criteria for episodic migraine will be randomly assigned to an evidence-informed, musculoskeletal focused multimodal chiropractic care (10 sessions over 14 weeks) plus enhanced UC vs. enhanced UC alone. Enhanced UC includes conventional care, migraine education materials, and biweekly check-in phone calls. Study specific aims include: 1) Determine safety and feasibility of the study design; 2) Provide preliminary data on the effectiveness of chiropractic care on migraine frequency, severity, duration and medication use; and 3) Provide preliminary estimates of the effects of chiropractic care on disability, health-related quality of life, and psychosocial well-being. DISCUSSION: Findings will be used to inform the design of a full-scale trial evaluating chiropractic care for women with episodic migraines.","journal":"Contemporary Clinical Trials Communications","year":2020,"id":86114,"datarank":0.5271122368491766,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.12090470668384508,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.12090470668384508,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":7,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":439609,"name":"Carolyn Bernstein","orcid":"0000-0002-1064-0808","position":1,"is_corresponding":false},{"id":439610,"name":"Matthew Kowalski","orcid":"0009-0006-6027-1592","position":2,"is_corresponding":false},{"id":439611,"name":"Julie P. Connor","orcid":"0000-0003-0967-7643","position":3,"is_corresponding":false},{"id":439612,"name":"Kamila Osypiuk","orcid":"0000-0002-7500-4562","position":4,"is_corresponding":false},{"id":411317,"name":"Cynthia R. Long","orcid":"0000-0002-1980-1620","position":5,"is_corresponding":false},{"id":411319,"name":"Robert Vining","orcid":"0000-0003-4672-4613","position":6,"is_corresponding":false},{"id":226503,"name":"Eric A. Macklin","orcid":"0000-0003-1618-3502","position":7,"is_corresponding":false},{"id":302168,"name":"Pamela M. Rist","orcid":"0000-0003-3543-045X","position":8,"is_corresponding":false},{"id":388766,"name":"Peter M. Wayne","orcid":"0000-0002-7561-3560","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:58:41.997408Z","pmid":"32043014","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}