{"doi":"10.1016/j.conb.2025.103074","title":"What’s the occasion? Phasic dopamine signaling and interoception","abstract":"Phasic dopamine is critically important in reward-related learning and assigns value to actions triggered by cues. Outcomes of actions in turn adjust the probability that a behavior will be repeated. That is, outcomes reinforce behavior-a process that also involves phasic dopamine. The value of actions and their outcomes, though, is ever fluctuating. Internal state-from physiological need through satiation-gates or applies gain to cue-evoked actions and the evaluation of their outcomes. We focus on how interoceptive signals may influence dopamine neurons to modify the phasic signaling underlying cue and reward-directed behaviors. We focus on interoceptive signals that arise from food or fluid deficit since the peripheral hormonal responses to such needs are relatively well established. A puzzle for the field is understanding how slowly accumulating and more tonic-like physiological signals are integrated to tune the brief and tightly time-locked phasic dopamine responses to environmental stimuli.","journal":"Current Opinion in Neurobiology","year":2025,"id":534051,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9479,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":548511,"name":"James E. McCutcheon","orcid":"0000-0002-6431-694X","position":1,"is_corresponding":false},{"id":329450,"name":"Mitchell F. Roitman","orcid":"0000-0003-3973-635X","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-19T02:51:43.451278Z","pmid":"40609165","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}