{"doi":"10.1016/j.conb.2025.103063","title":"Targeted cravings: Unraveling the drivers of nutrient-specific appetite","abstract":"Feeding behaviors are driven not just by caloric needs but also by nutrient-specific appetites, which guide animals to seek out foods that correct specific nutritional deficiencies and fulfill diverse nutrient requirements. Despite the longstanding behavioral manifestations of nutrient-specific appetites for various nutrients, progress in understanding the underlying mechanisms has been slow. In this review, we summarize the challenges and recent advances in the study of nutrient-specific appetites for macronutrients and micronutrients, focusing on sodium- and protein-specific hunger. We examine central mechanisms that integrate peripheral, interceptive, and internal state signals to drive nutrient-specific preference and ingestion. We also explore conserved features and interactions across different nutrient-specific appetites, and discuss their implications for future research.","journal":"Current Opinion in Neurobiology","year":2025,"id":533859,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1220692,"name":"Binod Aryal","orcid":"0000-0002-5570-5660","position":1,"is_corresponding":false},{"id":1220691,"name":"Tianji Ma","orcid":"0000-0003-0362-0654","position":2,"is_corresponding":false},{"id":1220690,"name":"Guangyan Wu","orcid":"0000-0002-7969-0192","position":3,"is_corresponding":false},{"id":562258,"name":"Qili Liu","orcid":"0000-0003-4839-3248","position":4,"is_corresponding":false},{"id":528794,"name":"Clare E. Hancock","orcid":"0000-0001-9324-9363","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:51:43.451278Z","pmid":"40494085","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}