{"doi":"10.1016/j.coi.2009.08.007","title":"AIRE in the thymus and beyond","abstract":null,"journal":"Current Opinion in Immunology","year":2009,"id":607265,"datarank":0.6952093482344455,"base_score":4.634728988229636,"endowment":4.634728988229636,"self_citation_contribution":0.6952093482344455,"citation_network_contribution":0.0,"self_endowment_contribution":0.6952093482344455,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":102,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1559235,"name":"Anne L Fletcher","orcid":null,"position":1,"is_corresponding":false},{"id":1203389,"name":"Mark S Anderson","orcid":null,"position":2,"is_corresponding":false},{"id":1559237,"name":"Shannon J Turley","orcid":null,"position":3,"is_corresponding":false},{"id":1559233,"name":"James M Gardner","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"AIRE in the thymus and beyond","abstract":"The maintenance of immunologic self-tolerance requires the coordination of multiple complementary systems. Studies of the Autoimmune Regulator (Aire) gene have revealed that Aire promotes self-tolerance partly by inducing the transcription of a wide array of tissue-specific antigens (TSAs), particularly in the thymus. The importance of Aire is highlighted by the fact that patients and mice defective in Aire expression develop a multi-organ autoimmune syndrome. In this review we discuss recent progress in our understanding of Aire's control of immune tolerance at the cellular and molecular levels, and also address the potential importance of Aire expression both in the thymus and in the peripheral lymphoid organs. The detection of both Aire and TSA expression by cell populations outside of the thymus raises the possibility that such expression may play a relevant role in the maintenance of self-tolerance.","is_dataset_classified":null,"base_score":4.634728988229636,"endowment":4.634728988229636,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19833494","pmcid":"PMC2787634","openalex_id":"https://openalex.org/W2023757010","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007618","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R01 EY016408","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P01 AI035297","title":null}],"total_grants":3,"fwci":7.3074,"citation_percentile":0.97974644,"influential_citations":0,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":12},{"year":2014,"count":6},{"year":2015,"count":4},{"year":2016,"count":4},{"year":2017,"count":5},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":6},{"year":2024,"count":4},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0952791509001824?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0952791509001824?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.coi.2009.08.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19833494","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787634","host_type":"repository"},{"url":"https://research.birmingham.ac.uk/en/publications/2b59271a-1054-45d0-9233-809b9d716716","host_type":"repository"}],"fields_of_study":["Adrenal Hormones and Disorders","T-cell and B-cell Immunology","Diabetes and associated disorders","Animals","Autoantigens","Autoimmune Diseases","Humans","Immune Tolerance","T-Lymphocytes","Thymus Gland","Transcription Factors","AIRE Protein"],"mesh_terms":["AIRE Protein","Animals","Autoantigens","Autoimmune Diseases","Humans","Immune Tolerance","T-Lymphocytes","Thymus Gland","Transcription Factors"],"keywords":["Autoimmune regulator","Central tolerance","Self Tolerance","Biology","Peripheral tolerance","Immune tolerance","Transcription factor","Immunology","Immune system","T cell","Lymphatic system","Regulator","Clonal deletion","Cell biology","Gene","Autoimmunity","T-cell receptor","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T06:03:41.498750Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}