{"doi":"10.1016/j.coemr.2020.09.002","title":"Targeting G protein–coupled receptor kinases to G protein–coupled receptors","abstract":null,"journal":"Current Opinion in Endocrine and Metabolic Research","year":2021,"id":606120,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1539256,"name":"Jeffrey L. Benovic","orcid":null,"position":1,"is_corresponding":false},{"id":340947,"name":"Sarah M. Sulon","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Targeting G protein–coupled receptor kinases to G protein–coupled receptors","abstract":"G protein-coupled receptors (GPCRs) interact with three protein families following agonist binding: heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs) and arrestins. GRK-mediated phosphorylation of GPCRs promotes arrestin binding to uncouple the receptor from G protein, a process called desensitization, and for many GPCRs, arrestin binding also promotes receptor endocytosis and intracellular signaling. Thus, GRKs play a central role in modulating GPCR signaling and localization. Here we review recent advances in this field which include additional insight into how GRKs target GPCRs and bias signaling, and the development of specific inhibitors to dissect GRK function in model systems.","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33718657","pmcid":"PMC7945687","openalex_id":"https://openalex.org/W3087108564","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL142310","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL136219","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"P01 HL114471","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R35 GM122541","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R35GM122541-05","title":"Regulation of G protein-coupled receptor signaling and trafficking"},{"funder_name":"National Institutes of Health","grant_id":"5R01HL136219-04","title":"Characterization of beta-arrestin-biased beta 2-adrenergic receptor signaling in cardiovascular function"},{"funder_name":"National Institutes of Health","grant_id":"3P01HL114471-08S2","title":"Novel Molecular Mechanisms Promote GPCR-Induced Bronchodilation in Asthma"},{"funder_name":"National Institutes of Health","grant_id":"1R01HL142310-01","title":"Structural and dynamic analysis of GRK interaction with G protein-coupled receptors"},{"funder_name":"National Institute of General Medical Sciences","grant_id":"","title":null},{"funder_name":"National Heart, Lung, and Blood Institute","grant_id":"","title":null}],"total_grants":10,"fwci":1.1182,"citation_percentile":0.7669564,"influential_citations":0,"citation_trend":[{"year":2022,"count":9},{"year":2023,"count":6},{"year":2024,"count":4},{"year":2025,"count":6},{"year":2026,"count":7}],"oa_status":"green","license":"Elsevier TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7945687","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7945687","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S2451965020300934?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2451965020300934?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.coemr.2020.09.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33718657","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945687","host_type":""}],"fields_of_study":["Receptor Mechanisms and Signaling","Mass Spectrometry Techniques and Applications","Neuropeptides and Animal Physiology","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["G protein-coupled receptor kinase","G protein-coupled receptor","Heterotrimeric G protein","Rhodopsin-like receptors","Cell biology","G protein","Biology","Arrestin","Receptor","Signal transduction","Biochemistry","Agonist","Metabotropic receptor","Protein kinase","Phosphorylation","Endocytosis","Desensitization","Cell signaling"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:56:25.172327Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}