{"doi":"10.1016/j.cmi.2025.04.034","title":"Maternal and child FUT2 secretor status affect gastroenteritis risk and gut microbiota composition in early life","abstract":null,"journal":"Clinical Microbiology and Infection","year":2025,"id":614415,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1583249,"name":"Casper-Emil T. Pedersen","orcid":null,"position":1,"is_corresponding":false},{"id":1583250,"name":"Anders Ulrik Eliasen","orcid":null,"position":2,"is_corresponding":false},{"id":657145,"name":"Nicklas Brustad","orcid":"0000-0001-6383-8845","position":3,"is_corresponding":false},{"id":1484063,"name":"Liang Chen","orcid":"0000-0002-6549-4510","position":4,"is_corresponding":false},{"id":494296,"name":"Ni Wang","orcid":"0000-0003-4961-7477","position":5,"is_corresponding":false},{"id":173181,"name":"Jie Jiang","orcid":null,"position":6,"is_corresponding":false},{"id":255254,"name":"Urvish Trivedi","orcid":"0000-0003-1541-6212","position":7,"is_corresponding":false},{"id":630676,"name":"Xuanji Li","orcid":"0000-0001-8835-488X","position":8,"is_corresponding":false},{"id":1583251,"name":"Søren Johannes Sørensen","orcid":null,"position":9,"is_corresponding":false},{"id":1583252,"name":"Bo L. Chawes","orcid":null,"position":10,"is_corresponding":false},{"id":241503,"name":"Jakob Stokholm","orcid":"0000-0003-4989-9769","position":11,"is_corresponding":false},{"id":255246,"name":"Jonathan Thorsen","orcid":"0000-0003-0200-0461","position":12,"is_corresponding":false},{"id":241476,"name":"Klaus Bønnelykke","orcid":"0000-0003-2003-1018","position":13,"is_corresponding":false},{"id":57807,"name":"Yang Luo","orcid":"0000-0001-7385-6166","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Maternal and child FUT2 secretor status affect gastroenteritis risk and gut microbiota composition in early life","abstract":"<h4>Objectives</h4>To investigate associations between maternal and child secretor status and early-life gastroenteritis risk, considering the roles of gut microbiota, breastfeeding, and daycare attendance.<h4>Methods</h4>In the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort (n = 700), parents recorded gastroenteritis episodes during the first 3 years of life. Secretor status, rs601338 in the FUT2 gene, was genotyped in both parents and children. The association between secretor status and gastroenteritis was assessed using quasi-Poisson regression. Faecal samples were collected at 1 week, 1 month, 1 year after birth. The interaction between secretor status, breastfeeding and daycare attendance were analysed through Cox regression.<h4>Results</h4>Maternal secretor status increased first-year gastroenteritis risk (incidence rate ratio [IRR] = 1.48, 95% CI: 1.05-2.16, p 0.033); child status increased second-year risk (IRR = 1.56, 95% CI: 1.11-2.27, p 0.015), especially after daycare attendance (interaction p 0.006). Maternal status associated with microbiota differences at 1 week (weighted UniFrac F = 2.4, R<sup>2</sup> = 0.47%, p 0.048) and 1 month (F = 3.3, R<sup>2</sup> = 0.62%, p 0.026); child status at 1 year (F = 2.5, R<sup>2</sup> = 0.45%, p 0.027). Secretor children showed lower Bacteroides vulgatus (median [interquartile range (IQR)]: 1.00% [0.04-12.92] vs. 5.00% [0.09-24.80], p 0.023) but higher Escherichia/Shigella (1.35% [IQR: 0.28-7.42] vs. 0.56% [IQR: 0.13-2.62], p 0.002). B. vulgatus mediated 14% of child status effects (average causal mediation effect IRR = 0.95, 95% CI: 0.89-0.99, p 0.014).<h4>Discussion</h4>Maternal and child FUT2 status demonstrates age-specific impacts on gastroenteritis and microbiota in early life, providing new insights into gastrointestinal health genetics and host-microbiome dynamics.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40339805","pmcid":null,"openalex_id":"https://openalex.org/W4410119303","authors":[],"funders":[],"total_grants":0,"fwci":1.2221,"citation_percentile":0.77190355,"influential_citations":0,"citation_trend":[{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1198743X25002162?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1198743X25002162?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cmi.2025.04.034","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40339805","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/ea94b9ea-84f0-4a27-9545-d1b51a6e17b9","host_type":"repository"}],"fields_of_study":["Gut microbiota and health","Infant Nutrition and Health","Probiotics and Fermented Foods","Humans","Gastrointestinal Microbiome","Gastroenteritis","Galactoside 2-alpha-L-fucosyltransferase","Female","Fucosyltransferases","Infant","Prospective Studies","Male","Feces","Child, Preschool","Risk Factors","Breast Feeding","Denmark","Genotype","Infant, Newborn","Adult"],"mesh_terms":["Gastrointestinal Microbiome","Galactoside 2-alpha-L-fucosyltransferase","Adult","Breast Feeding","Child, Preschool","Denmark","Feces","Female","Fucosyltransferases","Gastroenteritis","Genotype","Humans","Infant","Infant, Newborn","Male","Prospective Studies","Risk Factors"],"keywords":["Affect (linguistics)","Gut flora","Immunology","Medicine","Biology","Psychology","Maternal Influence","Gut Microbiome","Secretor Status","Gastroenteritis In Children","Fucosyltransferase-2 (Fut2)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T13:13:35.726621Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}