{"doi":"10.1016/j.cmet.2025.03.004","title":"Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation","abstract":null,"journal":"Cell Metabolism","year":2025,"id":652248,"datarank":0.6937459219926407,"base_score":4.624972813284271,"endowment":4.624972813284271,"self_citation_contribution":0.6937459219926407,"citation_network_contribution":0.0,"self_endowment_contribution":0.6937459219926407,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":101,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1701379,"name":"Luke A.J. O’Neill","orcid":null,"position":1,"is_corresponding":false},{"id":1701378,"name":"Eva M. Pålsson-McDermott","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation","abstract":"The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect of the immune response. Metabolic intermediates accumulate as a result of metabolic adaptations and mediate functions outside of metabolism in the regulation of immunity and inflammation. In macrophages, there has been a major focus on 3 metabolites linked to the Krebs cycle, itaconate, succinate, and fumarate, which have been shown to regulate multiple processes. Here, we discuss recent progress on these 3 metabolites with regard to their effect on macrophages in host defense and inflammatory diseases. We also consider the therapeutic opportunities presented from the mimicry of these metabolites or by targeting the enzymes that make or metabolize them in order to leverage the body's own anti-inflammatory response.","is_dataset_classified":null,"base_score":4.624972813284271,"endowment":4.624972813284271,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40169002","pmcid":null,"openalex_id":"https://openalex.org/W4409087851","authors":[],"funders":[{"funder_name":"Taighde Éireann – Research Ireland","grant_id":"19/FFP/6507","title":"Exploring Itaconate as a Critical Immunometabolite in Inflammation"},{"funder_name":"European Research Council","grant_id":"834370","title":"Metabolic crosstalk in the regulation of inflammation"},{"funder_name":"Irish Research eLibrary","grant_id":"unidentified","title":"unidentified"},{"funder_name":"European Research Council","grant_id":"","title":null}],"total_grants":4,"fwci":31.2159,"citation_percentile":0.99937753,"influential_citations":0,"citation_trend":[{"year":2025,"count":32},{"year":2026,"count":69}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.cmet.2025.03.004","host_type":"journal"},{"url":"https://doi.org/10.1016/j.cmet.2025.03.004","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S155041312500107X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S155041312500107X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40169002","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.cmet.2025.03.004","host_type":""}],"fields_of_study":["Tryptophan and brain disorders","Cytokine Signaling Pathways and Interactions","Endoplasmic Reticulum Stress and Disease","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Animals","Citric Acid Cycle","Fumarates","Humans","Inflammation","Macrophages","Succinates","Succinic Acid"],"keywords":["Inflammation","Citric acid cycle","Chemistry","Dimethyl fumarate","Cell biology","Biochemistry","Metabolism","Biology","Microbiology","Immunology","Krebs Cycle","Therapeutic Targets","Etc","Immunometabolism","Immunometabolites","Fumarates","Macrophages","Succinic Acid","Humans","Animals","Succinates"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T12:39:07.902856Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}