{"doi":"10.1016/j.cmet.2024.11.006","title":"Unveiling adipose populations linked to metabolic health in obesity","abstract":null,"journal":"Cell Metabolism","year":2025,"id":637666,"datarank":0.6329261557764161,"base_score":4.219507705176107,"endowment":4.219507705176107,"self_citation_contribution":0.6329261557764161,"citation_network_contribution":0.0,"self_endowment_contribution":0.6329261557764161,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":536843,"name":"Adhideb Ghosh","orcid":"0000-0002-5160-4571","position":1,"is_corresponding":false},{"id":1095853,"name":"Falko Noé","orcid":"0009-0002-3360-5455","position":2,"is_corresponding":false},{"id":27424,"name":"Wenfei Sun","orcid":"0000-0001-5762-6010","position":3,"is_corresponding":false},{"id":27425,"name":"Hua Dong","orcid":"0000-0002-8235-726X","position":4,"is_corresponding":false},{"id":872793,"name":"Peter Leary","orcid":"0000-0003-1430-6185","position":5,"is_corresponding":false},{"id":658308,"name":"Arne Dietrich","orcid":"0000-0002-8299-2386","position":6,"is_corresponding":false},{"id":351564,"name":"Anne Hoffmann","orcid":"0000-0003-3258-3397","position":7,"is_corresponding":false},{"id":21736,"name":"Matthias Blüher","orcid":"0000-0003-0208-2065","position":8,"is_corresponding":false},{"id":27438,"name":"Christian Wolfrum","orcid":"0000-0002-3862-6805","position":9,"is_corresponding":false},{"id":516115,"name":"Isabel Reinisch","orcid":"0000-0002-3587-4635","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Unveiling adipose populations linked to metabolic health in obesity","abstract":"Precision medicine is still not considered as a standard of care in obesity treatment, despite a large heterogeneity in the metabolic phenotype of individuals with obesity. One of the strongest factors influencing the variability in metabolic disease risk is adipose tissue (AT) dysfunction; however, there is little understanding of the link between distinct cell populations, cell-type-specific transcriptional programs, and disease severity. Here, we generated a comprehensive cellular map of subcutaneous and visceral AT of individuals with metabolically healthy and unhealthy obesity. By combining single-nucleus RNA-sequencing data with bulk transcriptomics and clinical parameters, we identified that mesothelial cells, adipocytes, and adipocyte-progenitor cells exhibit the strongest correlation with metabolic disease. Furthermore, we uncovered cell-specific transcriptional programs, such as the transitioning of mesothelial cells to a mesenchymal phenotype, that are involved in uncoupling obesity from metabolic disease. Together, these findings provide valuable insights by revealing biological drivers of clinical endpoints.","is_dataset_classified":null,"base_score":4.219507705176107,"endowment":4.219507705176107,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39694039","pmcid":null,"openalex_id":"https://openalex.org/W4405497278","authors":[],"funders":[{"funder_name":"Austrian Science Fund","grant_id":"J4760","title":null},{"funder_name":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","grant_id":"SNSF 215605","title":null},{"funder_name":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","grant_id":"SNSF 185011","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"CRC 1052","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"209933838","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Functional Genomics Center Zurich","grant_id":"","title":null}],"total_grants":7,"fwci":16.0143,"citation_percentile":0.99493004,"influential_citations":0,"citation_trend":[{"year":2025,"count":35},{"year":2026,"count":32}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.cmet.2024.11.006","host_type":"journal"},{"url":"https://doi.org/10.1016/j.cmet.2024.11.006","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1550413124004522?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1550413124004522?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39694039","host_type":"repository"},{"url":"https://dx.doi.org/10.3929/ethz-b-000715478","host_type":""},{"url":"https://dx.doi.org/10.5167/uzh-284614","host_type":""},{"url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=72860","host_type":""},{"url":"http://hdl.handle.net/20.500.11850/715478","host_type":""}],"fields_of_study":["Adipose Tissue and Metabolism","Adipokines, Inflammation, and Metabolic Diseases","Cardiovascular Disease and Adiposity","0303 health sciences","03 medical and health sciences","Humans","Obesity","Adipose Tissue","Male","Adipocytes","Female","Transcriptome","Middle Aged","Adult"],"mesh_terms":["Adipose Tissue","Adult","Female","Humans","Male","Metabolic Diseases","Middle Aged","Obesity","Adipocytes","Transcriptome"],"keywords":["Obesity","Adipose tissue","Biology","Bioinformatics","Medicine","Computational biology","Endocrinology","Adipocytes","Insulin resistance","Insulin sensitivity","visceral adipose tissue","Mesothelial Cells","Precision Medicine","Metabolically Healthy Obesity","Snrna-seq","Male","Adult","Adipocytes ; Adipose Tissue ; Insulin Resistance ; Insulin Sensitivity ; Mesothelial Cells ; Metabolically Healthy Obesity ; Obesity ; Precision Medicine ; Snrna-seq ; Visceral Adipose Tissue","Middle Aged","Humans","570 Life sciences; biology","Female","obesity; metabolically healthy obesity; adipose tissue; insulin sensitivity; insulin resistance; snRNA-seq; adipocytes; mesothelial cells; visceral adipose tissue; precision medicine","Transcriptome","610 Medicine & health"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T19:18:45.633898Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}