{"doi":"10.1016/j.cmet.2023.05.002","title":"Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood","abstract":"One of cannabis’ most iconic effects is the stimulation of hedonic high-calorie eating—the “munchies”—yet habitual cannabis users are, on average, leaner than non-users. We asked whether this phenotype might result from lasting changes in energy balance established during adolescence, when use of the drug often begins. We found that daily low-dose administration of cannabis’ intoxicating constituent, Δ9-tetrahydrocannabinol (THC), to adolescent male mice causes an adult metabolic phenotype characterized by reduced fat mass, increased lean mass and utilization of fat as fuel, partial resistance to diet-induced obesity and dyslipidemia, enhanced thermogenesis, and impaired cold- and β-adrenergic receptor-stimulated lipolysis. Further analyses revealed that this phenotype is associated with molecular anomalies in the adipose organ, including ectopic overexpression of muscle-associated proteins and heightened anabolic processing. Thus, adolescent exposure to THC may promote an enduring “pseudo-lean” state that superficially resembles healthy leanness but might in fact be rooted in adipose organ dysfunction.","journal":"Cell Metabolism","year":2023,"id":326170,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":422201,"name":"Kwang‐Mook Jung","orcid":"0000-0003-4096-6953","position":1,"is_corresponding":false},{"id":884126,"name":"Hye-Lim Lee","orcid":null,"position":2,"is_corresponding":false},{"id":654886,"name":"Johnny Le","orcid":"0000-0002-0245-5848","position":3,"is_corresponding":false},{"id":27427,"name":"Georgia Colleluori","orcid":"0000-0002-4908-9873","position":4,"is_corresponding":false},{"id":773690,"name":"Courtney Wood","orcid":"0000-0003-2263-1818","position":5,"is_corresponding":false},{"id":397673,"name":"Francesca Palese","orcid":"0000-0002-8426-8228","position":6,"is_corresponding":false},{"id":422205,"name":"Erica Squire","orcid":"0000-0003-2833-3379","position":7,"is_corresponding":false},{"id":670620,"name":"Jade Ramirez","orcid":"0000-0003-2454-3862","position":8,"is_corresponding":false},{"id":883582,"name":"Shiqi Su","orcid":"0000-0001-7812-2081","position":9,"is_corresponding":false},{"id":883581,"name":"Alexa Torrens","orcid":"0000-0001-7075-5669","position":10,"is_corresponding":false},{"id":397672,"name":"Yannick Fotio","orcid":"0000-0001-5193-2009","position":11,"is_corresponding":false},{"id":749647,"name":"Lingyi Tang","orcid":"0000-0002-4804-7241","position":12,"is_corresponding":false},{"id":289624,"name":"Clinton Yu","orcid":"0000-0002-2931-5474","position":13,"is_corresponding":false},{"id":1045043,"name":"Qin Yang","orcid":"0000-0002-9792-4431","position":14,"is_corresponding":false},{"id":289627,"name":"Lan Huang","orcid":"0000-0002-3140-4687","position":15,"is_corresponding":false},{"id":492409,"name":"Nicholas V. DiPatrizio","orcid":"0000-0001-8423-0695","position":16,"is_corresponding":false},{"id":225539,"name":"Cholsoon Jang","orcid":"0000-0001-6651-4213","position":17,"is_corresponding":false},{"id":27436,"name":"Saverio Cinti","orcid":"0000-0003-0362-5017","position":18,"is_corresponding":false},{"id":397675,"name":"Daniele Piomelli","orcid":"0000-0002-2983-774X","position":19,"is_corresponding":false},{"id":352766,"name":"Lin Lin","orcid":"0000-0003-4702-7190","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"37267956","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}