{"doi":"10.1016/j.cmet.2022.12.006","title":"Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals","abstract":"Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a daily cycle of feeding and fasting. In both animals and humans, TRF has pleiotropic health benefits that arise from multiple organ systems, yet the molecular basis of TRF-mediated benefits is not well understood. Here, we subjected mice to isocaloric ad libitum feeding (ALF) or TRF of a western diet and examined gene expression changes in samples taken from 22 organs and brain regions collected every 2 h over a 24-h period. We discovered that TRF profoundly impacts gene expression. Nearly 80% of all genes show differential expression or rhythmicity under TRF in at least one tissue. Functional annotation of these changes revealed tissue- and pathway-specific impacts of TRF. These findings and resources provide a critical foundation for future mechanistic studies and will help to guide human time-restricted eating (TRE) interventions to treat various disease conditions with or without pharmacotherapies.","journal":"Cell Metabolism","year":2023,"id":315989,"datarank":0.7218276533058626,"base_score":4.812184355372417,"endowment":4.812184355372417,"self_citation_contribution":0.7218276533058626,"citation_network_contribution":0.0,"self_endowment_contribution":0.7218276533058626,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":122,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":635091,"name":"Terry Lin","orcid":"0000-0002-1766-6066","position":1,"is_corresponding":false},{"id":635089,"name":"Amandine Chaix","orcid":"0000-0001-7007-197X","position":2,"is_corresponding":false},{"id":84659,"name":"April E. Williams","orcid":"0000-0001-9281-8528","position":3,"is_corresponding":false},{"id":583310,"name":"Hiep D. Le","orcid":"0000-0003-4147-6454","position":4,"is_corresponding":false},{"id":696376,"name":"Hugo Calligaro","orcid":"0000-0003-0334-6974","position":5,"is_corresponding":false},{"id":1018563,"name":"Ramesh Ramasamy","orcid":"0000-0002-5433-1417","position":6,"is_corresponding":false},{"id":266877,"name":"Ling Huang","orcid":"0000-0002-5135-6088","position":7,"is_corresponding":false},{"id":407408,"name":"Satchidananda Panda","orcid":"0000-0002-7855-0091","position":8,"is_corresponding":false},{"id":410829,"name":"Shaunak Deota","orcid":"0000-0002-4862-7414","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:06:32.274501Z","pmid":"36599299","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}