{"doi":"10.1016/j.cmet.2022.10.011","title":"Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response","abstract":null,"journal":"Cell Metabolism","year":2022,"id":603013,"datarank":0.7050720548688626,"base_score":4.700480365792417,"endowment":4.700480365792417,"self_citation_contribution":0.7050720548688626,"citation_network_contribution":0.0,"self_endowment_contribution":0.7050720548688626,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":109,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1546738,"name":"Aitana Victoria Genzor","orcid":null,"position":1,"is_corresponding":false},{"id":1546739,"name":"Anna Constance Vind","orcid":null,"position":2,"is_corresponding":false},{"id":1546740,"name":"Laura Ryder","orcid":null,"position":3,"is_corresponding":false},{"id":137138,"name":"Mark Stoneley","orcid":null,"position":4,"is_corresponding":false},{"id":1546742,"name":"Sébastien Chamois","orcid":null,"position":5,"is_corresponding":false},{"id":1546744,"name":"René Dreos","orcid":null,"position":6,"is_corresponding":false},{"id":252476,"name":"Cathrine Nordgaard","orcid":"0000-0002-9817-1961","position":7,"is_corresponding":false},{"id":1452509,"name":"Frederike Sass","orcid":"0000-0002-6144-7661","position":8,"is_corresponding":false},{"id":252471,"name":"Melanie Blasius","orcid":"0000-0001-5032-2209","position":9,"is_corresponding":false},{"id":1546747,"name":"Aida Rodríguez López","orcid":null,"position":10,"is_corresponding":false},{"id":1546748,"name":"Sólveig Hlín Brynjólfsdóttir","orcid":null,"position":11,"is_corresponding":false},{"id":252475,"name":"Kasper Langebjerg Andersen","orcid":"0000-0002-5127-113X","position":12,"is_corresponding":false},{"id":490551,"name":"Anne E. 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Among these is the ribotoxic stress response (RSR), where ribosomal sensing by the MAP3K ZAKα leads to activation of p38 and JNK kinases. Despite these insights, the physiological ramifications of ribosomal impairment and downstream RSR signaling remain elusive. Here, we show that stalling of ribosomes is sufficient to activate ZAKα. In response to amino acid deprivation and full nutrient starvation, RSR impacts on the ensuing metabolic responses in cells, nematodes, and mice. The RSR-regulated responses in these model systems include regulation of AMPK and mTOR signaling, survival under starvation conditions, stress hormone production, and regulation of blood sugar control. In addition, ZAK −/− male mice present a lean phenotype. Our work highlights impaired ribosomes as metabolic signals and demonstrates a role for RSR signaling in metabolic regulation.","is_dataset_classified":null,"base_score":4.653960350157523,"endowment":4.653960350157523,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36384144","pmcid":"PMC9763090","openalex_id":"https://openalex.org/W4309243361","authors":[],"funders":[{"funder_name":"European Research Council","grant_id":"863911 \\u2014PHYRIST","title":null},{"funder_name":"Novo Nordisk Foundation","grant_id":"NNF20SA0064340","title":null},{"funder_name":"Novo Nordisk Foundation","grant_id":"NNF18CC0034900","title":null},{"funder_name":"Swiss National Science Foundation","grant_id":"179190","title":"Molecular mechanisms and physiological signals underlying daily rhythms in translation"},{"funder_name":"Swiss National Science Foundation","grant_id":"141735","title":"NCCR RNA & disease: Understanding the role of RNA biology in disease mechanisms (phase I)"},{"funder_name":"NNF Center for Basic Metabolic Research","grant_id":"Clemmensen Group","title":null},{"funder_name":"Lundbeck Foundation","grant_id":"R338-2019-2996","title":null},{"funder_name":"Lundbeck Foundation","grant_id":"R190-2014-4037","title":null},{"funder_name":"Novo Nordisk Foundation","grant_id":"unidentified","title":"unidentified"},{"funder_name":"European Commission","grant_id":"863911","title":"Physiological roles of the Ribotoxic Stress Response"},{"funder_name":"Horizon 2020 Framework Programme","grant_id":"","title":null},{"funder_name":"European Research Council","grant_id":"","title":null},{"funder_name":"Horizon 2020","grant_id":"","title":null}],"total_grants":13,"fwci":9.359,"citation_percentile":0.99135947,"influential_citations":0,"citation_trend":[{"year":2023,"count":18},{"year":2024,"count":31},{"year":2025,"count":38},{"year":2026,"count":17}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S1550413122004892/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1550413122004892/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1550413122004892?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1550413122004892?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cmet.2022.10.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36384144","host_type":"repository"},{"url":"https://serval.unil.ch/notice/serval:BIB_7C7E5C26F023","host_type":"repository"},{"url":"https://iris.unil.ch/handle/iris/139107","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9763090","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/43a2e27f-90e0-42a8-8b55-93c3424b76b8","host_type":"repository"},{"url":"https://iris.unil.ch/bitstreams/879f0683-30c1-41c2-ba3f-4360eaecf637/download","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9763090","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.cmet.2022.10.011","host_type":""},{"url":"http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_7C7E5C26F0233","host_type":""},{"url":"https://serval.unil.ch/resource/serval:BIB_7C7E5C26F023.P001/REF.pdf","host_type":""},{"url":"https://curis.ku.dk/ws/files/329742169/1_s2.0_S1550413122004892_main.pdf","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.cmet.2022.10.011","host_type":""}],"fields_of_study":["Endoplasmic Reticulum Stress and Disease","Diet, Metabolism, and Disease","Microbial Metabolic Engineering and Bioproduction","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Male","Ribosomes","Stress, Physiological","Protein Biosynthesis","MAP Kinase Kinase Kinases","Mice"],"keywords":["Metabolic pathway","Fight-or-flight response","Integrated stress response","Cell biology","Signal transduction","Signal pathway","Biology","Translation (biology)","Computational biology","Chemistry","Bioinformatics","Genetics","Biochemistry","Metabolism","Messenger RNA","Gene","Metabolic regulation","Mtor","Mouse Models","Ampk","Ribotoxic Stress Response","Fgf21","Amino Acid Starvation","Ribosome Collision","Zak-alpha","Animals; 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