{"doi":"10.1016/j.cmet.2019.08.009","title":"Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice","abstract":null,"journal":"Cell Metabolism","year":2019,"id":632029,"datarank":3.8253963837939278,"base_score":4.948759890378168,"endowment":4.948759890378168,"self_citation_contribution":0.7423139835567254,"citation_network_contribution":3.0830824002372026,"self_endowment_contribution":0.7423139835567254,"citer_contribution":3.0830824002372026,"corpus_percentile":null,"corpus_rank":null,"citation_count":140,"citer_count":127,"citers_with_citation_signal":100,"citers_with_endowment":100,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1032845,"name":"Jacqueline A. Koehler","orcid":null,"position":1,"is_corresponding":false},{"id":987189,"name":"Laurie L. Baggio","orcid":null,"position":2,"is_corresponding":false},{"id":7379,"name":"Alvin C. Powers","orcid":"0000-0003-1941-5786","position":3,"is_corresponding":false},{"id":268338,"name":"Darleen A. Sandoval","orcid":"0000-0003-3669-3278","position":4,"is_corresponding":false},{"id":237001,"name":"Daniel J. Drucker","orcid":"0000-0001-6688-8127","position":5,"is_corresponding":false},{"id":1638167,"name":"Youngmi Song","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice","abstract":"The importance of pancreatic versus intestinal-derived GLP-1 for glucose homeostasis is controversial. We detected active GLP-1 in the mouse and human pancreas, albeit at extremely low levels relative to glucagon. Accordingly, to elucidate the metabolic importance of intestinal proglucagon-derived peptides (PGDPs), we generated mice with reduction of Gcg expression within the distal (Gcg<sup>DistalGut-/-</sup>) or entire (Gcg<sup>Gut-/-</sup>) gut. Substantial reduction of gut Gcg expression markedly reduced circulating levels of GLP-1, and impaired glucose homeostasis, associated with increased levels of GIP, and accelerated gastric emptying. Gcg<sup>DistalGut-/-</sup> mice similarly exhibited lower circulating GLP-1 and impaired oral glucose tolerance. Nevertheless, plasma levels of insulin remained normal following glucose administration in the absence of gut-derived GLP-1. Collectively, our findings identify the essential importance of gut-derived PGDPs for maintaining levels of circulating GLP-1, control of gastric emptying, and glucose homeostasis.","is_dataset_classified":null,"base_score":4.948759890378168,"endowment":4.948759890378168,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31495689","pmcid":"PMC8140521","openalex_id":"https://openalex.org/W2972217240","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"P60 DK020593","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"UC4 DK104211","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"U01 DK089572","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"154321","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R24 DK106755","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"P30 DK020593","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"UC4 DK108120","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Novo Nordisk","grant_id":"","title":null},{"funder_name":"Banting and Best Diabetes Centre, University of Toronto","grant_id":"","title":null}],"total_grants":10,"fwci":9.4598,"citation_percentile":0.98829166,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2020,"count":19},{"year":2021,"count":22},{"year":2022,"count":23},{"year":2023,"count":15},{"year":2024,"count":30},{"year":2025,"count":20},{"year":2026,"count":9}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S1550413119304383/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1550413119304383/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cmet.2019.08.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31495689","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8140521","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.cmet.2019.08.009","host_type":""}],"fields_of_study":["Diabetes Treatment and Management","Pancreatic function and diabetes","Diet and metabolism studies","0301 basic medicine","03 medical and health sciences","Animals","Gastrointestinal Microbiome","Glucose","Homeostasis","Humans","Insulin","Mice","Peptides","Proglucagon"],"mesh_terms":["Gastrointestinal Microbiome","Animals","Glucose","Homeostasis","Humans","Insulin","Peptides","Mice","Proglucagon"],"keywords":["Proglucagon","Glucose homeostasis","Homeostasis","Glucagon-like peptide-1","Incretin","Biology","Endocrinology","Internal medicine","Cell biology","Diabetes mellitus","Medicine","Type 2 diabetes","Insulin resistance","Pancreas","Insulin","Glucagon","Intestine","Diabetes","GIP","Islet","Glp-1","Enteroendocrine Cell","Mice","Glucose","Animals","Humans","Peptides","Gastrointestinal Microbiome"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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