{"doi":"10.1016/j.cmet.2018.01.015","title":"Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point","abstract":null,"journal":"Cell Metabolism","year":2018,"id":656506,"datarank":0.8013501377947218,"base_score":5.342334251964811,"endowment":5.342334251964811,"self_citation_contribution":0.8013501377947218,"citation_network_contribution":0.0,"self_endowment_contribution":0.8013501377947218,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":208,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":767213,"name":"R. Damaris Molano","orcid":"0009-0005-7291-3380","position":1,"is_corresponding":false},{"id":1583999,"name":"Jonathan R. Weitz","orcid":null,"position":2,"is_corresponding":false},{"id":434282,"name":"Midhat H. Abdulreda","orcid":"0000-0002-0146-5876","position":3,"is_corresponding":false},{"id":721003,"name":"Dora M. Berman","orcid":"0000-0001-7817-9387","position":4,"is_corresponding":false},{"id":831682,"name":"Barbara Leibiger","orcid":null,"position":5,"is_corresponding":false},{"id":831244,"name":"Ingo B. Leibiger","orcid":"0000-0002-1766-8942","position":6,"is_corresponding":false},{"id":513360,"name":"Norma S. Kenyon","orcid":"0000-0003-3157-339X","position":7,"is_corresponding":false},{"id":316559,"name":"Camillo Ricordi","orcid":"0000-0001-8092-7153","position":8,"is_corresponding":false},{"id":1259435,"name":"Antonello Pileggi","orcid":"0000-0001-7819-2813","position":9,"is_corresponding":false},{"id":288079,"name":"Alejandro Caicedo","orcid":"0000-0002-3765-3529","position":10,"is_corresponding":false},{"id":1541977,"name":"Per-Olof Berggren","orcid":null,"position":11,"is_corresponding":false},{"id":1713769,"name":"Rayner Rodriguez-Diaz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point","abstract":"Every animal species has a signature blood glucose level or glycemic set point. These set points are different, and the normal glycemic levels (normoglycemia) of one species would be life threatening for other species. Mouse normoglycemia can be considered diabetic for humans. The biological determinants of the glycemic set point remain unclear. Here we show that the pancreatic islet imposes its glycemic set point on the organism, making it the bona fide glucostat in the body. Moreover, and in contrast to rodent islets, glucagon input from the alpha cell to the insulin-secreting beta cell is necessary to fine-tune the distinctive human set point. These findings affect transplantation and regenerative approaches to treat diabetes because restoring normoglycemia may require more than replacing only the beta cells. Furthermore, therapeutic strategies using glucagon receptor antagonists as hypoglycemic agents need to be reassessed, as they may reset the overall glucostat in the organism.","is_dataset_classified":null,"base_score":5.342334251964811,"endowment":5.342334251964811,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29514065","pmcid":"PMC5872154","openalex_id":"https://openalex.org/W2792395170","authors":[],"funders":[{"funder_name":"American Diabetes Association","grant_id":"1-17-ICTS-052","title":null},{"funder_name":"American Diabetes Association","grant_id":"R21DK114418","title":null},{"funder_name":"National Institutes of Health","grant_id":"F32DK083226","title":null},{"funder_name":"National Institutes of Health","grant_id":"K01DK097194","title":null},{"funder_name":"National Institutes of Health","grant_id":"R56DK084321","title":null},{"funder_name":"National Institutes of Health","grant_id":"R01DK111538","title":null},{"funder_name":"National Institutes of Health","grant_id":"R01DK113093","title":null},{"funder_name":"National Institutes of Health","grant_id":"R21ES025673","title":null},{"funder_name":"Novo Nordisk Fonden","grant_id":"NNF17OC0026726","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK084321","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK124527","title":null},{"funder_name":"European Research Council","grant_id":"338936","title":"An in vivo imaging approach to understand pancreatic beta-cell signal-transduction"},{"funder_name":"Novo Nordisk Fonden","grant_id":"NNF12OC1016557","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01DK111538-02","title":"Cholinergic signaling in the human pancreatic islet"},{"funder_name":"Novo Nordisk Foundation","grant_id":"unidentified","title":"unidentified"},{"funder_name":"National Institutes of Health","grant_id":"3R01DK084321-03S1","title":"The role of innervation for hormone secretion in human islets"},{"funder_name":"National Institutes of Health","grant_id":"5R01DK113093-03","title":"Harnessing Innervation to Promote Pancreatic Islet Function"},{"funder_name":"National Institutes of Health","grant_id":"1F32DK083226-01A1","title":"Noninvasive two-photon imaging of pancreatic islet graft rejection in the eye"},{"funder_name":"National Institutes of Health","grant_id":"5R21DK114418-03","title":"The role of the delta cell in islet homeostasis"},{"funder_name":"National Institutes of Health","grant_id":"5R21ES025673-02","title":"Imaging mitochondrial signaling in B-cells ectopically implanted in the eye"},{"funder_name":"European Commission","grant_id":"727306","title":"Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications"},{"funder_name":"National Institutes of Health","grant_id":"1K01DK097194-01A1","title":"Role of macrophages in pancreatic islet graft rejection"},{"funder_name":"Diabetes Research Institute Foundation","grant_id":"","title":null},{"funder_name":"Knut och Alice Wallenbergs Stiftelse","grant_id":"","title":null},{"funder_name":"Familjen Erling-Perssons Stiftelse","grant_id":"","title":null},{"funder_name":"Novo Nordisk Fonden","grant_id":"","title":null},{"funder_name":"Karolinska Institutet","grant_id":"","title":null},{"funder_name":"Stichting af Jochnick Foundation","grant_id":"","title":null},{"funder_name":"Vetenskapsrådet","grant_id":"","title":null}],"total_grants":29,"fwci":21.677,"citation_percentile":0.99756924,"influential_citations":0,"citation_trend":[{"year":2018,"count":6},{"year":2019,"count":27},{"year":2020,"count":28},{"year":2021,"count":37},{"year":2022,"count":28},{"year":2023,"count":25},{"year":2024,"count":27},{"year":2025,"count":22},{"year":2026,"count":8}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S1550413118300676/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1550413118300676/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1550413118300676?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1550413118300676?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cmet.2018.01.015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29514065","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC5872154","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5872154","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.cmet.2018.01.015","host_type":""},{"url":"http://dx.doi.org/10.1016/j.cmet.2018.01.015","host_type":""}],"fields_of_study":["Pancreatic function and diabetes","Diabetes and associated disorders","Diabetes 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