{"doi":"10.1016/j.cmet.2012.06.002","title":"Replicative and Chronological Aging in Saccharomyces cerevisiae","abstract":null,"journal":"Cell Metabolism","year":2012,"id":688575,"datarank":0.9656627474604603,"base_score":6.437751649736401,"endowment":6.437751649736401,"self_citation_contribution":0.9656627474604603,"citation_network_contribution":0.0,"self_endowment_contribution":0.9656627474604603,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":624,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1798900,"name":"Gerald S. Shadel","orcid":null,"position":1,"is_corresponding":false},{"id":287812,"name":"Matt Kaeberlein","orcid":"0000-0002-1311-3421","position":2,"is_corresponding":false},{"id":1798901,"name":"Brian Kennedy","orcid":null,"position":3,"is_corresponding":false},{"id":1798899,"name":"Valter D. Longo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Replicative and Chronological Aging in Saccharomyces cerevisiae","abstract":"Saccharomyces cerevisiae has directly or indirectly contributed to the identification of arguably more mammalian genes that affect aging than any other model organism. Aging in yeast is assayed primarily by measurement of replicative or chronological life span. Here, we review the genes and mechanisms implicated in these two aging model systems and key remaining issues that need to be addressed for their optimization. Because of its well-characterized genome that is remarkably amenable to genetic manipulation and high-throughput screening procedures, S. cerevisiae will continue to serve as a leading model organism for studying pathways relevant to human aging and disease.","is_dataset_classified":null,"base_score":6.437751649736401,"endowment":6.437751649736401,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22768836","pmcid":null,"openalex_id":"https://openalex.org/W2012418095","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"5R01AG025135-05","title":"Chronological Age-Dependent Genomic Instability in Yeast"},{"funder_name":"National Institutes of Health","grant_id":"5P01AG034906-03","title":"Animal and Biostatics Core"},{"funder_name":"National Institutes of Health","grant_id":"2P01AG034906-06A1","title":"Dietary Restriction, GH/IGF-l & Mechanisms of Cellular Protection and Regeneration"},{"funder_name":"National Institutes of Health","grant_id":"5R01AG020642-05","title":"Mechanisms of Longevity Regulation in Yeast"},{"funder_name":"National Institutes of Health","grant_id":"1R01AG039390-01A1","title":"Defining the Mechanisms of genotype-dependent responses to caloric restriction"},{"funder_name":"National Institutes of Health","grant_id":"5R01AG033373-02","title":"TOR, Translation and Aging"}],"total_grants":6,"fwci":14.9034,"citation_percentile":0.99929128,"influential_citations":0,"citation_trend":[{"year":2012,"count":12},{"year":2013,"count":43},{"year":2014,"count":68},{"year":2015,"count":37},{"year":2016,"count":50},{"year":2017,"count":37},{"year":2018,"count":43},{"year":2019,"count":62},{"year":2020,"count":52},{"year":2021,"count":51},{"year":2022,"count":45},{"year":2023,"count":38},{"year":2024,"count":34},{"year":2025,"count":33},{"year":2026,"count":18}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S1550413112002379/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S1550413112002379/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1550413112002379?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1550413112002379?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cmet.2012.06.002","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22768836","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3392685","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.cmet.2012.06.002","host_type":""},{"url":"https://dx.doi.org/10.1016/j.cmet.2012.06.002","host_type":""}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Fungal and yeast genetics research","Plant Gene Expression Analysis","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Cell Cycle","Genes, Fungal","Humans","Longevity","Nutritional Physiological Phenomena","Saccharomyces cerevisiae","Oxidative Stress","Saccharomyces cerevisiae Proteins","Microbial Viability"],"keywords":["Saccharomyces cerevisiae","Model organism","Organism","Biology","Cellular Aging","Yeast","Gene","Computational biology","Genome","Identification (biology)","Genetics","Disease","Medicine","Telomere","Microbial Viability","Saccharomyces cerevisiae Proteins","Physiology","Cell Cycle","Genes, Fungal","Longevity","Cell Biology","Oxidative Stress","Animals","Humans","Nutritional Physiological Phenomena","Molecular Biology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T17:37:21.567688Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}