{"doi":"10.1016/j.clnu.2024.09.045","title":"Soy protein β-conglycinin ameliorates pressure overload-induced heart failure by increasing short-chain fatty acid (SCFA)-producing gut microbiota and intestinal SCFAs","abstract":null,"journal":"Clinical Nutrition","year":2024,"id":616564,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1589705,"name":"Miku Kobayashi","orcid":null,"position":1,"is_corresponding":false},{"id":1589706,"name":"Mikako Ito","orcid":null,"position":2,"is_corresponding":false},{"id":176093,"name":"Hiroki Matsui","orcid":"0000-0002-0122-2735","position":3,"is_corresponding":false},{"id":201076,"name":"Koji Ohashi","orcid":null,"position":4,"is_corresponding":false},{"id":87066,"name":"Toyoaki Murohara","orcid":"0000-0003-2723-6243","position":5,"is_corresponding":false},{"id":166954,"name":"Jun-ichi Takeda","orcid":null,"position":6,"is_corresponding":false},{"id":882530,"name":"Jun Ueyama","orcid":"0000-0003-0660-2726","position":7,"is_corresponding":false},{"id":192390,"name":"Masaaki Hirayama","orcid":"0000-0003-4804-4208","position":8,"is_corresponding":false},{"id":1390649,"name":"Kinji Ohno","orcid":"0000-0002-1529-2750","position":9,"is_corresponding":false},{"id":1589704,"name":"Nozomi Furukawa","orcid":"0000-0001-6494-6776","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Soy protein β-conglycinin ameliorates pressure overload-induced heart failure by increasing short-chain fatty acid (SCFA)-producing gut microbiota and intestinal SCFAs","abstract":"BACKGROUND AND AIMS: Soybeans and their ingredients have antioxidant and anti-inflammatory effects on cardiovascular diseases. β-Conglycinin (β-CG), a major constituent of soy proteins, is protective against obesity, hypertension, and chronic kidney disease, but its effects on heart failure remain to be elucidated. We tested the effects of β-CG on left ventricular (LV) remodeling in pressure overload-induced heart failure. METHODS: A transverse aortic constriction (TAC)-induced pressure overload was applied to the heart in 7-week-old C57BL6 male mice that were treated with β-CG, GlcNAc, or sodium propionate. Gut microbiota was analyzed by 16S rRNA sequencing. Fecal short-chain fatty acids (SCFAs) were quantified by GC-MS. The effects of oral antibiotics were examined in β-CG-fed mice. RESULTS: β-CG ameliorated impaired cardiac contractions, cardiac hypertrophy, and myocardial fibrosis in TAC-operated mice. As β-CG is a highly glycosylated protein, we examined the effects of GlcNAc. GlcNAc had similar but less efficient effects on LV remodeling compared to β-CG. β-CG increased three major SCFA-producing intestinal bacteria, as well as fecal concentrations of SCFAs, in sham- and TAC-operated mice. Oral administration of antibiotics nullified the effects of β-CG in TAC-operated mice by markedly reducing SCFA-producing intestinal bacteria and fecal SCFAs. In contrast, oral administration of sodium propionate, one of SCFAs, ameliorated LV remodeling in TAC-operated mice to a similar extent as β-CG. CONCLUSIONS: β-CG was protective against TAC-induced LV remodeling, which was likely to be mediated by increased SCFA-producing gut microbiota and increased intestinal SCFAs. Modified β-CG and/or derivatives arising from β-CG are expected to be developed as prophylactic and/or therapeutic agents to ameliorate devastating symptoms in heart failure.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39447394","pmcid":null,"openalex_id":"https://openalex.org/W4403045162","authors":[],"funders":[],"total_grants":0,"fwci":6.0904,"citation_percentile":0.97130897,"influential_citations":0,"citation_trend":[{"year":2025,"count":12},{"year":2026,"count":6}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.clinicalnutritionjournal.com/article/S0261-5614(24)00356-X/pdf","host_type":"journal"},{"url":"https://www.clinicalnutritionjournal.com/article/S0261-5614(24)00356-X/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S026156142400356X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S026156142400356X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.clnu.2024.09.045","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39447394","host_type":"repository"}],"fields_of_study":["Cardiac Fibrosis and Remodeling","Cardiovascular Function and Risk Factors","Gut microbiota and health"],"mesh_terms":["Gastrointestinal Microbiome","Animals","Disease Models, Animal","Fatty Acids, Volatile","Feces","Globulins","Heart Failure","Male","Mice, Inbred C57BL","Propionates","Ventricular Remodeling","Soybean Proteins","Mice","Antigens, Plant","Seed Storage Proteins"],"keywords":["Medicine","Short-chain fatty acid","Gut flora","Soy protein","Pressure overload","Heart failure","Fatty acid","Biochemistry","Food science","Internal medicine","Immunology","Pathology","Biology","Butyrate","Gut Microbiota","Short-chain Fatty Acids","Β-conglycinin"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T23:13:43.527681Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}