{"doi":"10.1016/j.clnu.2022.03.026","title":"An in-line digestive cartridge increases enteral fat and vitamin absorption in a porcine model of short bowel syndrome","abstract":"BACKGROUND & AIMS: Short bowel syndrome (SBS) occurs after intestinal loss resulting in parenteral nutrition dependence and micronutrient deficiencies, which may lead to life-limiting complications. ALC-078 is a cartridge containing immobilized lipase that connects in-line with enteral feeding sets and digests fats in enteral nutrition (EN). In this study, we evaluate the efficacy of ALC-078 to improve fat and nutrient absorption in a porcine SBS model. METHODS: Fifteen male Yorkshire piglets were assessed. Animals were randomized to no intestinal resection (n = 5), 75% resection (n = 5), or 75% resection + ALC-078 (n = 5). After recovery, animals were treated for 14 days. Piglets received 60% of nutrition from continuous EN and 40% from chow. The degree of fat malabsorption was determined by the coefficient of fat absorption (CFA) following a 72-h stool collection. Body weight, fat-soluble vitamins, and nutritional markers were assessed. RESULTS: Adverse events were similar across the three groups (P = 1.00). ALC-078-treated animals had similar weight gain compared to resected piglets. Resected animals had a lower CFA compared to unresected controls (79.3% vs. 95.2%, P = 0.01) while there was no significant difference in the ALC-078 animals (87.1% vs. 95.2%, P = 0.19). Between Study Days 1 and 15, ALC-078 animals had increased concentrations of vitamin D (12.2 vs. 8.7 ng/mL, P = 0.0006), and vitamin E (4.3 vs. 2.5 mg/L, P = 0.03). These markers did not significantly change in untreated resected animals. CONCLUSION: ALC-078 increases the absorption of fat-soluble vitamins and may improve fat malabsorption. Future studies should determine whether ALC-078 can reduce PN dependence and if these findings translate to human patients with SBS.","journal":"Clinical Nutrition","year":2022,"id":283317,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":650348,"name":"Scott C. Fligor","orcid":"0000-0003-4591-9371","position":1,"is_corresponding":false},{"id":511146,"name":"Jordan D. Secor","orcid":null,"position":2,"is_corresponding":false},{"id":510500,"name":"Lumeng J. Yu","orcid":"0000-0003-0370-4444","position":3,"is_corresponding":false},{"id":444935,"name":"Amy Pan","orcid":"0000-0002-7199-7704","position":4,"is_corresponding":false},{"id":362250,"name":"Paul D. Mitchell","orcid":"0000-0001-7034-1669","position":5,"is_corresponding":false},{"id":959726,"name":"Greta Loring","orcid":"0000-0002-8800-4393","position":6,"is_corresponding":false},{"id":959727,"name":"Eric First","orcid":"0000-0002-6423-1444","position":7,"is_corresponding":false},{"id":960170,"name":"Arthur Nedder","orcid":null,"position":8,"is_corresponding":false},{"id":960171,"name":"Robin M Grammer","orcid":null,"position":9,"is_corresponding":false},{"id":960172,"name":"Brenda Pattison","orcid":null,"position":10,"is_corresponding":false},{"id":354285,"name":"Kathleen M. Gura","orcid":"0000-0002-0431-896X","position":11,"is_corresponding":false},{"id":354288,"name":"Mark Puder","orcid":"0000-0002-7941-2926","position":12,"is_corresponding":false},{"id":650349,"name":"Savas T. Tsikis","orcid":"0000-0001-7588-8372","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T00:29:23.777809Z","pmid":"35413571","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}