{"doi":"10.1016/j.clnu.2021.12.037","title":"U-shaped association between dietary copper intake and new-onset hypertension","abstract":null,"journal":"Clinical Nutrition","year":2022,"id":672423,"datarank":0.5926865577872142,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.0,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236983,"name":"Huan Li","orcid":"0009-0002-2551-9127","position":1,"is_corresponding":false},{"id":698329,"name":"Chengzhang Liu","orcid":"0000-0002-6408-7518","position":2,"is_corresponding":false},{"id":698328,"name":"Mengyi Liu","orcid":"0009-0008-9149-3272","position":3,"is_corresponding":false},{"id":320410,"name":"Zhuxian Zhang","orcid":"0000-0002-7504-0758","position":4,"is_corresponding":false},{"id":550923,"name":"Yuanyuan Zhang","orcid":"0000-0002-5708-9718","position":5,"is_corresponding":false},{"id":800010,"name":"Chun Zhou","orcid":"0000-0001-6611-1967","position":6,"is_corresponding":false},{"id":321925,"name":"Qinqin Li","orcid":null,"position":7,"is_corresponding":false},{"id":885414,"name":"Ziliang Ye","orcid":null,"position":8,"is_corresponding":false},{"id":885413,"name":"Qimeng Wu","orcid":null,"position":9,"is_corresponding":false},{"id":935916,"name":"Jianping Jiang","orcid":"0000-0003-1120-6883","position":10,"is_corresponding":false},{"id":935918,"name":"Guobao Wang","orcid":"0000-0003-4050-3385","position":11,"is_corresponding":false},{"id":935917,"name":"Min Liang","orcid":"0000-0002-0613-2077","position":12,"is_corresponding":false},{"id":1110940,"name":"Jing Nie","orcid":"0000-0002-1709-3288","position":13,"is_corresponding":false},{"id":289676,"name":"Fan Fan Hou","orcid":"0000-0003-3117-7418","position":14,"is_corresponding":false},{"id":320414,"name":"Xianhui Qin","orcid":"0000-0001-7812-7982","position":15,"is_corresponding":false},{"id":320411,"name":"Panpan He","orcid":"0000-0003-4238-5837","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"U-shaped association between dietary copper intake and new-onset hypertension","abstract":"<h4>Aims</h4>To investigate the relationship of dietary copper intake with new-onset hypertension among Chinese adults.<h4>Methods</h4>A total of 12,245 participants who were free of hypertension at baseline from the China Health and Nutrition Survey (CHNS) were included. Dietary intake was measured by 3 consecutive 24-h dietary recalls combined with a household food inventory. New-onset hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up.<h4>Results</h4>During a median follow-up of 6.1 years, 4304 participants developed new-onset hypertension. Overall, the associations between dietary copper intake and new-onset hypertension followed a U-shape (P for nonlinearity <0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary copper intake (per SD increment: HR, 0.71; 95% CI, 0.57-0.88) in participants with copper intake <1.57 mg/day, and increased with the increment of dietary copper intake (per SD increment: HR, 1.09; 95% CI: 1.07-1.12) in participants with copper intake ≥1.57 mg/day.<h4>Conclusions</h4>There was a U-shaped association between dietary copper intake and new-onset hypertension in general Chinese adults, with an inflection point at about 1.57 mg/day. Our results emphasized the importance of maintaining optimal copper intake levels for the primary prevention of hypertension.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35030528","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"R24 HD050924","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"T32 HD007168","title":null},{"funder_name":"FIC NIH HHS","grant_id":"D43 TW009077","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD038700","title":null},{"funder_name":"FIC NIH HHS","grant_id":"D43 TW007709","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"P2C HD050924","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"","title":null}],"total_grants":7,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0261561421006051?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0261561421006051?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Hypertension","Copper","Antihypertensive Agents","Diet","Nutrition Surveys","Follow-Up Studies","Eating","Adult","Middle Aged","China","Female","Male"],"keywords":["Mineral nutrient","Nationwide Cohort Study","New-onset Hypertension","Dietary Copper Intake"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T09:03:35.277485Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}