{"doi":"10.1016/j.clnesp.2025.07.029","title":"Early alterations in nutritional indices in metabolic dysfunction-associated steatotic liver disease-related cirrhosis","abstract":null,"journal":"Clinical Nutrition ESPEN","year":2025,"id":642559,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1671431,"name":"Shinya Furukawa","orcid":null,"position":1,"is_corresponding":false},{"id":407515,"name":"Osamu Yoshida","orcid":"0000-0002-5015-0045","position":2,"is_corresponding":false},{"id":1671432,"name":"Ayumi Kanamoto","orcid":null,"position":3,"is_corresponding":false},{"id":1671433,"name":"Yoshimasa Murakami","orcid":null,"position":4,"is_corresponding":false},{"id":1671434,"name":"Masumi Miyazaki","orcid":null,"position":5,"is_corresponding":false},{"id":1671435,"name":"Makoto Morita","orcid":null,"position":6,"is_corresponding":false},{"id":1671436,"name":"Sho Ishikawa","orcid":null,"position":7,"is_corresponding":false},{"id":1671437,"name":"Yuki Numata","orcid":null,"position":8,"is_corresponding":false},{"id":1671438,"name":"Hironobu Nakaguchi","orcid":null,"position":9,"is_corresponding":false},{"id":205501,"name":"Yoshiko Nakamura","orcid":null,"position":10,"is_corresponding":false},{"id":1671439,"name":"Mitsuhito Koizumi","orcid":null,"position":11,"is_corresponding":false},{"id":1671440,"name":"Takao Watanabe","orcid":null,"position":12,"is_corresponding":false},{"id":19084,"name":"Yasunori Yamamoto","orcid":"0000-0002-6943-6887","position":13,"is_corresponding":false},{"id":1507821,"name":"Yoshio Tokumoto","orcid":null,"position":14,"is_corresponding":false},{"id":1611020,"name":"Masashi Hirooka","orcid":null,"position":15,"is_corresponding":false},{"id":1671441,"name":"Hirohito Mori","orcid":null,"position":16,"is_corresponding":false},{"id":1671442,"name":"Eiji Takeshita","orcid":null,"position":17,"is_corresponding":false},{"id":1671443,"name":"Teru Kumagi","orcid":null,"position":18,"is_corresponding":false},{"id":692064,"name":"Yoshio Ikeda","orcid":"0000-0001-8900-4216","position":19,"is_corresponding":false},{"id":640244,"name":"Masanori Abe","orcid":"0000-0002-5641-4996","position":20,"is_corresponding":false},{"id":1507825,"name":"Bunzo Matsuura","orcid":null,"position":21,"is_corresponding":false},{"id":1228280,"name":"Kanako Inoue","orcid":"0000-0002-3691-263X","position":22,"is_corresponding":false},{"id":1671444,"name":"Mika Takeshima","orcid":null,"position":23,"is_corresponding":false},{"id":1671445,"name":"Yoshiko Nagai","orcid":null,"position":24,"is_corresponding":false},{"id":1671446,"name":"Kumiko Toshimitsu","orcid":null,"position":25,"is_corresponding":false},{"id":1507822,"name":"Yoichi Hiasa","orcid":null,"position":26,"is_corresponding":false},{"id":1404150,"name":"Teruki Miyake","orcid":"0000-0002-9905-5356","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Early alterations in nutritional indices in metabolic dysfunction-associated steatotic liver disease-related cirrhosis","abstract":"BACKGROUND AND AIM: Metabolic dysfunction-associated steatotic liver disease (MASLD) is primarily driven by relative overnutrition. Dietary restrictions and weight loss through exercise are known to improve this condition. However, as MASLD progresses, adequate nutritional intake is required to prevent decompensated cirrhosis. Therefore, appropriate nutritional assessment tools are needed to guide the transition from dietary restriction to adequate nutritional intake. However, early risk indicators of malnutrition in MASLD, particularly before decompensated cirrhosis develops, remain unclear. This study aimed to explore nutritional markers indicative of deterioration in MASLD with cirrhosis. METHODS: This cross-sectional study included 154 patients (aged 18-79 years) diagnosed with MASLD by liver biopsy between October 2007 and June 2024 at Ehime University Hospital and received nutritional assessments during hospitalization. RESULTS: The Royal Free Hospital Nutritional Prioritizing Tool classified all patients as low risk. Multivariate analysis, adjusted for age, sex, body mass index, creatinine levels, and nonalcoholic fatty liver disease activity score, identified lower albumin, lower cholinesterase, higher hemoglobin A1c, lower total cholesterol, and lower low-density (LDL) cholesterol as independently associated with advanced fibrosis. However, no significant differences were observed in body composition, nutritional intake, and non-protein respiratory quotients. CONCLUSIONS: Blood indices reflecting protein syntheses, including albumin and cholinesterase, were useful makers for comprehending the change in nutritional status in MASLD-related cirrhosis. Clinicians should consider these markers when initiating timely changes in nutritional interventions for MASLD-related cirrhosis.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40675488","pmcid":null,"openalex_id":"https://openalex.org/W4412464737","authors":[],"funders":[],"total_grants":0,"fwci":0.7713,"citation_percentile":0.71993903,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://www.clinicalnutritionespen.com/article/S2405-4577(25)01780-2/pdf","host_type":"journal"},{"url":"https://www.clinicalnutritionespen.com/article/S2405-4577(25)01780-2/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2405457725017802?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2405457725017802?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.clnesp.2025.07.029","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40675488","host_type":"repository"}],"fields_of_study":["Liver Disease and Transplantation","Liver Disease Diagnosis and Treatment","Nutrition and Health in Aging","Humans","Middle Aged","Male","Female","Adult","Cross-Sectional Studies","Liver Cirrhosis","Nutritional Status","Aged","Young Adult","Adolescent","Nutrition Assessment","Biomarkers","Malnutrition","Fatty Liver","Non-alcoholic Fatty Liver Disease","Body Mass Index"],"mesh_terms":["Adolescent","Adult","Aged","Cross-Sectional Studies","Fatty Liver","Female","Humans","Liver Cirrhosis","Male","Middle Aged","Nutritional Status","Biomarkers","Nutrition Assessment","Body Mass Index","Malnutrition","Young Adult","Non-alcoholic Fatty Liver Disease"],"keywords":["Medicine","Cirrhosis","Internal medicine","Fatty liver","Liver disease","Gastroenterology","Disease","Liver dysfunction","Nutritional indices","Malnutrition","Nutritional intervention","Metabolic Dysfunction-associated Steatotic Liver Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T00:13:08.324529Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}