{"doi":"10.1016/j.clnesp.2022.12.004","title":"Docosahexaenoic acid (DHA) intake estimated from a 7-question survey identifies pregnancies most likely to benefit from high-dose DHA supplementation","abstract":"BACKGROUND: Two randomized trials found women with low blood docosahexaenoic acid (DHA; an omega 3 fatty acid) had fewer early preterm births (<34 weeks gestation) if they were assigned to high dose DHA supplementation, however, there is currently no capacity for clinicians who care for pregnancies to obtain a blood assessment of DHA. Determining a way to identify women with low DHA intake whose risk could be lowered by high dose DHA supplementation is desired. OBJECTIVE: To determine if assessing DHA intake can identify pregnancies that benefit from high dose DHA supplementation. STUDY DESIGN: This secondary analysis used birth data from 1310 pregnant women who completed a 7-question food frequency questionnaire (DHA-FFQ) at 16.8 ± 2.5 weeks gestation that is validated to assess DHA status. They were then randomly assigned to a standard (200 mg/day) or high dose (800 or 1000 mg/day) DHA supplement for the remainder of pregnancy. Bayesian logistic regressions were fitted for early preterm birth and preterm birth as a function of DHA intake and assigned DHA dose. RESULTS: Participants who consumed less than 150 mg/day DHA prior to 20 weeks' gestation (n = 810/1310, 58.1%) had a lower Bayesian posterior probability (pp) of early preterm birth if they were assigned to high dose DHA supplementation (1.4% vs 3.9%, pp = 0.99). The effect on preterm birth (<37 weeks) was also significant (11.3% vs 14.8%, pp = 0.97). CONCLUSION: The DHA-FFQ can identify pregnancies that will benefit most from high dose DHA supplementation and reduce the risk of preterm birth. The DHA-FFQ is low burden to providers and patients and could be easily implemented in obstetrical practice.","journal":"Clinical Nutrition ESPEN","year":2022,"id":262696,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":640203,"name":"Sarah Crawford","orcid":"0000-0002-4868-8057","position":1,"is_corresponding":false},{"id":918559,"name":"Gene Lee","orcid":"0000-0003-2662-1000","position":2,"is_corresponding":false},{"id":640202,"name":"Alexandra R. Brown","orcid":"0000-0002-1594-3269","position":3,"is_corresponding":false},{"id":919040,"name":"J T Camargo","orcid":null,"position":4,"is_corresponding":false},{"id":640200,"name":"Elizabeth H. Kerling","orcid":"0000-0001-7707-070X","position":5,"is_corresponding":false},{"id":31034,"name":"Byron J. Gajewski","orcid":"0000-0001-7589-8247","position":6,"is_corresponding":false},{"id":640199,"name":"Christina J. Valentine","orcid":"0000-0002-5467-0785","position":7,"is_corresponding":false},{"id":294101,"name":"Kathleen M. Gustafson","orcid":"0000-0003-3225-5086","position":8,"is_corresponding":false},{"id":537738,"name":"Emily DeFranco","orcid":"0000-0002-0164-5703","position":9,"is_corresponding":false},{"id":612692,"name":"Susan E. Carlson","orcid":"0000-0003-3579-1685","position":10,"is_corresponding":false},{"id":918558,"name":"Danielle Christifano","orcid":"0000-0001-9368-2028","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T00:26:25.074177Z","pmid":"36657936","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}