{"doi":"10.1016/j.clinre.2017.10.005","title":"A new pathway to eSCAPe lipotoxicity","abstract":null,"journal":"Clinics and Research in Hepatology and Gastroenterology","year":2018,"id":648108,"datarank":0.1697390105393312,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.06576693345533938,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.06576693345533938,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1123506,"name":"Catherine Postic","orcid":"0000-0002-1875-6960","position":1,"is_corresponding":false},{"id":1688854,"name":"Fadila Benhamed","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A new pathway to eSCAPe lipotoxicity","abstract":"The molecular mechanisms underlying fatty liver progression towards more severe syndromes are complex and only partially understood. Studies have recently reported that lipotoxic fatty acid metabolites are instrumental in the development of hepatocyte injury in the context of fatty liver disease. The recent study by Papazyan et al. published in Cell Metabolism (2016;24(6):863-874) addresses this issue and reveals that rescuing de novo fatty acid synthesis (lipogenesis) through the activation of the transcription factor SREBP-1c can prevent lethality as well as severe lipotoxicity caused by a combined deficiency in lipogenesis and β-oxidation. Altogether, this study reveals that optimizing lipid signals generated by lipogenesis through SREBP-1c can help redirect fatty acids toward beneficial actions, by buffering lipotoxic lipid intermediates even in the setting of lipid overload.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29174379","pmcid":null,"openalex_id":"https://openalex.org/W2770114531","authors":[],"funders":[{"funder_name":"ChroME Network","grant_id":"H2020-MSCA-ITN-2015-675610","title":null},{"funder_name":"Foundation for the Medical Research","grant_id":"DEQ20150331744","title":null},{"funder_name":"National Agency for Research","grant_id":"ANR-12BSV1-0025-ObeLiP","title":null},{"funder_name":"National Agency for Research","grant_id":"ANR-15-CE14-0026-Hepatokind","title":null}],"total_grants":4,"fwci":0.1637,"citation_percentile":0.55647057,"influential_citations":0,"citation_trend":[{"year":2020,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S221074011730222X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S221074011730222X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.clinre.2017.10.005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29174379","host_type":"repository"},{"url":"https://hal.science/hal-03144735","host_type":"repository"}],"fields_of_study":["Liver Disease Diagnosis and Treatment","Lipid metabolism and biosynthesis","Peroxisome Proliferator-Activated Receptors","Biology","Medicine"],"mesh_terms":["Fatty Acids","Fatty Liver","Humans","Liver","Hepatocytes","Lipogenesis","Sterol Regulatory Element Binding Protein 1"],"keywords":["Lipotoxicity","Lipogenesis","Fatty liver","Hepatocyte","Fatty acid","Lipid metabolism","Context (archaeology)","Sterol regulatory element-binding protein","Transcription factor","Beta oxidation","Fatty acid metabolism","Endocrinology","Internal medicine","Medicine","Cell biology","Biochemistry","Chemistry","Biology","Disease","Insulin resistance","Diabetes mellitus","Gene","Srebp-1c","De Novo Lipogenesis","Lipotoxicity;nafld"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:14:59.450812Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}