{"doi":"10.1016/j.clinph.2009.09.034","title":"Occlusion of bidirectional plasticity by preceding low-frequency stimulation in the human motor cortex","abstract":null,"journal":"Clinical Neurophysiology","year":2010,"id":624472,"datarank":0.637274286307404,"base_score":4.248495242049359,"endowment":4.248495242049359,"self_citation_contribution":0.637274286307404,"citation_network_contribution":0.0,"self_endowment_contribution":0.637274286307404,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1614317,"name":"Nikolai H. Jung","orcid":null,"position":1,"is_corresponding":false},{"id":1614318,"name":"Florian Mainberger","orcid":null,"position":2,"is_corresponding":false},{"id":1614319,"name":"Nicola G. Kuhnke","orcid":null,"position":3,"is_corresponding":false},{"id":1614320,"name":"Matthias Cronjaeger","orcid":null,"position":4,"is_corresponding":false},{"id":584744,"name":"Volker Mall","orcid":"0000-0003-3135-3709","position":5,"is_corresponding":false},{"id":1207136,"name":"Igor Delvendahl","orcid":"0000-0002-6151-2363","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Occlusion of bidirectional plasticity by preceding low-frequency stimulation in the human motor cortex","abstract":"<h4>Objective</h4>Low-frequency stimulation, which does not induce long-term potentiation (LTP) or long-term potentiation (LTD) by itself, suppresses consecutive LTP or LTD induction in vitro. We tested whether a similar interaction occurs in the human motor cortex.<h4>Methods</h4>LTP- or LTD-like plasticity was induced using paired associative stimulation (PAS) with 25 and 10 ms interstimulus interval and conditioned by suprathreshold repetitive transcranial magnetic stimulation (rTMS) at a frequency of 0.1Hz.<h4>Results</h4>RTMS completely abolished the significant increase of motor-evoked potential (MEP) amplitudes after PAS(25 ms) (PAS(25 ms) only: 1.05+/-0.14 to 1.76+/-0.66 mV, p=0.001; rTMS+PAS(25 ms): 1.08+/-0.18 to 1.02+/-0.44 mV, n.s.) and also abolished the significant decrease of MEP amplitudes after PAS(10 ms) (PAS(10 ms) only: 1.00+/-0.14 to 0.73+/-0.32 mV; rTMS+PAS(10 ms): 1.15+/-0.35 to 1.25+/-0.43 mV, p=0.006). RTMS alone did not significantly alter MEP amplitudes but increased SICI and LICI.<h4>Conclusions</h4>Low frequency stimulation increases intracortical inhibition and occludes LTP- and LTD-like plasticity in the human motor cortex.<h4>Significance</h4>This finding supports the concept that metaplasticity in the human motor cortex follows similar rules as metaplasticity in in vitro experiments.","is_dataset_classified":null,"base_score":4.248495242049359,"endowment":4.248495242049359,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20074998","pmcid":null,"openalex_id":"https://openalex.org/W1968590628","authors":[],"funders":[],"total_grants":0,"fwci":5.654,"citation_percentile":0.95802609,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":12},{"year":2014,"count":5},{"year":2015,"count":8},{"year":2016,"count":5},{"year":2017,"count":3},{"year":2018,"count":4},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":2},{"year":2025,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1388245709007780?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1388245709007780?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.clinph.2009.09.034","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20074998","host_type":"repository"}],"fields_of_study":["Transcranial Magnetic Stimulation Studies","Muscle activation and electromyography studies","Intraoperative Neuromonitoring and Anesthetic Effects","Adult","Biophysics","Cortical Spreading Depression","Electric Stimulation","Electromyography","Evoked Potentials, Motor","Female","Humans","Male","Median Nerve","Motor Cortex","Multivariate Analysis","Muscle, Skeletal","Neural Inhibition","Neuronal Plasticity","Reaction Time","Time Factors","Transcranial Magnetic Stimulation","Young Adult"],"mesh_terms":["Adult","Biophysics","Electric Stimulation","Electromyography","Female","Humans","Male","Median Nerve","Motor Cortex","Neural Inhibition","Neuronal Plasticity","Reaction Time","Cortical Spreading Depression","Time Factors","Multivariate Analysis","Muscle, Skeletal","Evoked Potentials, Motor","Transcranial Magnetic Stimulation","Young Adult"],"keywords":["Long-term potentiation","Transcranial magnetic stimulation","Motor cortex","Neuroscience","Stimulation","CTBS","Synaptic plasticity","Neuroplasticity","Chemistry","Evoked potential","Metaplasticity","Psychology","Primary motor cortex","Receptor","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T03:52:14.278663Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}