{"doi":"10.1016/j.clim.2024.110214","title":"Defining remission in childhood-onset lupus: PReS-endorsed consensus definitions by an international task force","abstract":"OBJECTIVE: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. METHODS: The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. RESULTS: The Task Force proposed two definitions of remission: 'cSLE clinical remission on steroids (cCR)' and 'cSLE clinical remission off steroids (cCR-0)'. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0-3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. CONCLUSIONS: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research.","journal":"Clinical Immunology","year":2024,"id":425000,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9087,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":301585,"name":"Amita Aggarwal","orcid":"0000-0002-2187-5186","position":1,"is_corresponding":false},{"id":1039293,"name":"Jenny Ainsworth","orcid":"0000-0001-8375-2205","position":2,"is_corresponding":false},{"id":1039294,"name":"Eslam Al‐Abadi","orcid":"0000-0002-1999-6341","position":3,"is_corresponding":false},{"id":288732,"name":"Tadej Avčin","orcid":"0000-0001-8409-9092","position":4,"is_corresponding":false},{"id":1039741,"name":"Lynette Bortey","orcid":null,"position":5,"is_corresponding":false},{"id":970154,"name":"Jon M. 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