{"doi":"10.1016/j.clim.2024.110175","title":"The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution","abstract":null,"journal":"Clinical Immunology","year":2024,"id":603833,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104692,"name":"Sophia Koutsogiannaki","orcid":"0000-0003-3555-1681","position":1,"is_corresponding":false},{"id":104690,"name":"Koichi Yuki","orcid":"0000-0003-1312-585X","position":2,"is_corresponding":false},{"id":872943,"name":"Fahd Alhamdan","orcid":"0000-0003-1617-9781","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution","abstract":"Recognizing immune dysregulation as a hallmark of sepsis pathophysiology, leukocytes have attracted major attention of investigation. While adult and pediatric sepsis are clinically distinct, their immunological delineation remains limited. Single cell technologies facilitated the characterization of immune signatures. We tackled to delineate immunological profiles of pediatric sepsis at a single-cell level by analyzing blood samples from six septic children, at both acute and recovery phases, and four healthy children. 16 single-cell transcriptomic datasets were analyzed and compared to adult sepsis dataset. We showed a unique shift in neutrophil subpopulations and functions between acute and recovery phases, along with the regulatory role of resistin. Neutrophil signatures were comparable between adult and pediatric sepsis. Innate-like CD4 T cells were predominantly and uniquely observed in acute phase of pediatric sepsis. Our study serves as a rich source of information about the phenotypic diversity and trajectory of circulating immune cells during pediatric sepsis.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38460893","pmcid":"PMC11009045","openalex_id":"https://openalex.org/W4392545995","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"R21 HD099194","title":null},{"funder_name":"NICHD","grant_id":"","title":null}],"total_grants":2,"fwci":2.5642,"citation_percentile":0.90056698,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"green","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11009045/pdf/nihms-1974480.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11009045/pdf/nihms-1974480.pdf","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S1521661624000664?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1521661624000664?httpAccept=text/plain","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11009045","host_type":"repository"},{"url":"https://doi.org/10.1016/j.clim.2024.110175","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38460893","host_type":"repository"}],"fields_of_study":["Sepsis Diagnosis and Treatment","Immune Response and Inflammation","Neuroinflammation and Neurodegeneration Mechanisms"],"mesh_terms":["Adult","Child","Humans","Neutrophils","CD4-Positive T-Lymphocytes","Sepsis","Gene Expression Profiling","Transcriptome"],"keywords":["Sepsis","Immune system","Immunology","Immune dysregulation","Innate immune system","Medicine","Phenotype","Biology","Gene","Immune Dysfunction","Pediatric Sepsis","Single Cell Rna Sequencing"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T22:49:50.658690Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}