{"doi":"10.1016/j.clim.2023.109750","title":"Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD","abstract":"Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial. Cu-IUD usage showed the most extensive transcriptomic changes, and was associated with inflammatory and anti-viral host responses. DMPA-IM usage was enriched for pathways associated with T cell responses. LNG implant had the mildest effect on endocervical gene expression, and was associated with growth factor signaling. These data provide a mechanistic basis for the diverse influence that varying contraceptives have on the FGT.","journal":"Clinical Immunology","year":2023,"id":386672,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":307178,"name":"Christina Balle","orcid":"0000-0003-3439-3992","position":1,"is_corresponding":false},{"id":244967,"name":"Gregory K. Tharp","orcid":"0000-0003-3075-755X","position":2,"is_corresponding":false},{"id":381611,"name":"Sydney A. Nelson","orcid":"0000-0001-8632-4855","position":3,"is_corresponding":false},{"id":924886,"name":"Melanie Gasper","orcid":"0000-0001-7169-1847","position":4,"is_corresponding":false},{"id":965277,"name":"Bryan Brown","orcid":null,"position":5,"is_corresponding":false},{"id":333625,"name":"Arghavan Alisoltani","orcid":"0000-0003-3638-2218","position":6,"is_corresponding":false},{"id":394447,"name":"Maricianah Onono","orcid":"0000-0001-6847-8762","position":7,"is_corresponding":false},{"id":459399,"name":"Thesla Palanee‐Phillips","orcid":"0000-0002-0052-5830","position":8,"is_corresponding":false},{"id":1155552,"name":"Gonsagrie Nair","orcid":null,"position":9,"is_corresponding":false},{"id":1155553,"name":"Hosseana Ayele","orcid":null,"position":10,"is_corresponding":false},{"id":315893,"name":"Laura Noël‐Romas","orcid":null,"position":11,"is_corresponding":false},{"id":307189,"name":"Jo‐Ann S. Passmore","orcid":"0000-0002-1471-4245","position":12,"is_corresponding":false},{"id":314054,"name":"Adam Burgener","orcid":"0000-0002-2303-5738","position":13,"is_corresponding":false},{"id":299053,"name":"Renee Heffron","orcid":"0000-0001-6039-0352","position":14,"is_corresponding":false},{"id":307190,"name":"Heather B. Jaspan","orcid":"0000-0002-0745-6073","position":15,"is_corresponding":false},{"id":232942,"name":"Steven E. Bosinger","orcid":"0000-0002-2116-5061","position":16,"is_corresponding":false},{"id":382361,"name":"Prachi Mehrotra Gupta","orcid":null,"position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":null,"created_at":"2026-07-19T01:18:00.717763Z","pmid":"37660744","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}