{"doi":"10.1016/j.clim.2021.108699","title":"The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection","abstract":null,"journal":"Clinical Immunology","year":2021,"id":617254,"datarank":1.3143091246659422,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.7992110439931702,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.7992110439931702,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":29,"citers_with_citation_signal":27,"citers_with_endowment":27,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1591722,"name":"Kleio-Maria Verrou","orcid":null,"position":1,"is_corresponding":false},{"id":871545,"name":"Konstantinos Stellos","orcid":"0000-0002-0194-0825","position":2,"is_corresponding":false},{"id":155812,"name":"Petros P. Sfikakis","orcid":null,"position":3,"is_corresponding":false},{"id":502724,"name":"Dimitrios Paraskevis","orcid":"0000-0001-6167-7152","position":4,"is_corresponding":false},{"id":1591718,"name":"Nikolaos I. Vlachogiannis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection","abstract":"RNA editing is a fundamental biological process with 2 major forms, namely adenosine-to-inosine (A-to-I, recognized as A-to-G) and cytosine-to-uracil (C-to-U) deamination, mediated by ADAR and APOBEC enzyme families, respectively. A-to-I RNA editing has been shown to directly affect the genome/transcriptome of RNA viruses with significant repercussions for viral protein synthesis, proliferation and infectivity, while it also affects recognition of double-stranded RNAs by cytosolic receptors controlling the host innate immune response. Recent evidence suggests that RNA editing may be present in SARS-CoV-2 genome/transcriptome. The majority of mapped mutations in SARS-CoV-2 genome are A-to-G/U-to-C(opposite strand) and C-to-U/G-to-A(opposite strand) substitutions comprising potential ADAR-/APOBEC-mediated deamination events. A single nucleotide substitution can have dramatic effects on SARS-CoV-2 infectivity as shown by the D614G(A-to-G) substitution in the spike protein. Future studies utilizing serial sampling from patients with COVID-19 are warranted to delineate whether RNA editing affects viral replication and/or the host immune response to SARS-CoV-2.","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33639276","pmcid":"PMC7904470","openalex_id":"https://openalex.org/W3129888584","authors":[],"funders":[],"total_grants":0,"fwci":1.9993,"citation_percentile":0.87277686,"influential_citations":0,"citation_trend":[{"year":2021,"count":7},{"year":2022,"count":7},{"year":2023,"count":6},{"year":2024,"count":7},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7904470","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7904470","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S152166162100036X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S152166162100036X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.clim.2021.108699","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33639276","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7904470","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7904470?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["RNA regulation and disease","Viral Infections and Immunology Research","Viral gastroenteritis research and epidemiology","APOBEC Deaminases","Adenosine Deaminase","COVID-19","Humans","Immunity, Innate","Mutation","RNA Editing","RNA Viruses","RNA, Double-Stranded","RNA-Binding Proteins","SARS-CoV-2"],"mesh_terms":["APOBEC Deaminases","COVID-19","SARS-CoV-2","Adenosine Deaminase","Humans","Immunity, Innate","Mutation","RNA Viruses","RNA, Double-Stranded","RNA-Binding Proteins","RNA Editing"],"keywords":["ADAR","RNA editing","Biology","RNA","APOBEC","Virology","APOBEC3G","Transcriptome","Genome","Viral replication","Genetics","Infectivity","Virus","Gene","Gene expression","Mutations","innate immunity","Viral Infections","A-to-i Rna Editing","Sars-cov-2"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T01:13:23.357694Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}